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. 2021 Sep 21;8:673042. doi: 10.3389/fmolb.2021.673042

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Copyright © 2021 Boisson, Noël, Saiselet, Rodrigues-Vitória, Thomas, Fontsa, Sofronii, Naveaux, Duvillier, Craciun, Larsimont, Awada, Detours, Willard-Gallo and Garaud.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune profiling of breast cancer. (A–D) Representative images of tumor-infiltrating lymphocyte (TIL) and tertiary lymphoid structure (TLS) in FFPE breast cancer sections detected by (A) hematoxylin and eosin staining (H&E), (B) chromogenic IHC (cIHC), and (C, D) multiplex IHC (mIHC). (E) Quantification of immune cells in stromal, tumoral, and TLS areas using InForm and PhenoptrReports. (F) Spatial distribution of immune cells including CD8⁺ T cells closest to individual CK⁺ tumor cells and T_FH cells touching proliferating B cells in a TLS. H&E and cIHC slides were scanned at ×40 magnification and the images are displayed at ×5 and ×40 magnification. mIHC slides were scanned at ×20 magnification.