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. 2021 Sep 21;12:688493. doi: 10.3389/fimmu.2021.688493

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Copyright © 2021 Rivas, Durmaz, Kloetgen, Chin, Chen, Bhinder, Koren, Viny, Scharer, Boss, Elemento, Mason and Melnick

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aberrant gene expression program in Smc3 haploinsufficient tumors. (A) Development and experimental design for study of lymphomas in Bcl6 and Smc3/Bcl6 mice, where conditional heterozygous deletion of Smc3 was directed towards B-cells entering the GC reaction by crossing to the Cγ1-Cre strain. (B) Volcano plot showing differentially expressed genes in Bcl6 and Smc3/Bcl6 tumor cell RNA-sequencing. (C–E) Gene set enrichment analysis plots in Bcl6 vs Smc3/Bcl6 RNA-sequencing. Smc3_vs_WT_CC_DN (6), DECP_vs_DECN_UP, GCB_GFP_MYC_UP (39), B220_shKMT2D_DN (43) and TET2_KO_DN (44).