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. 2021 Sep 21;12:688493. doi: 10.3389/fimmu.2021.688493

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Copyright © 2021 Rivas, Durmaz, Kloetgen, Chin, Chen, Bhinder, Koren, Viny, Scharer, Boss, Elemento, Mason and Melnick

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mutational analysis of Smc3/Bcl6 tumors. (A, B) Mutational burden of Bcl6 and Smc3/Bcl6 tumors assessed by exon capture analysis. (A) number of mutations per tumor. (B) Genomic gain and loss in Bcl6 and Smc3/Bcl6 tumors. (C) Oncoprint depicting AID-induced mutations in 125 non-immunoglobulin genes in Bcl6 (n=5) and Smc3/Bcl6 (n=10) tumors. Mutation frequency is shown in the right bar plot for Bcl6 (blue) and Smc3/Bcl6 (red). Mutations were classified as missense mutations, nonsense-mediated decay transcript variants, splice regions variants, stop gained, or synonymous variants, as indicated by the color key on the left of the oncoprint.