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. 2021 Sep 21;9:697831. doi: 10.3389/fcell.2021.697831

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Copyright © 2021 Yang, Peng and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PAK2 upregulation notably counteracted RP11-499E18.1 overexpression-triggered tumor-suppressing effects. The plasmids pcDNA3.1, pcDNA-RP11-499E18.1, and pcDNA-RP11-499E18.1 + pcDNA-PAK2 were respectively transfected into CaOV3 and SKOV3 cells. (A) RP11-499E18.1 was successfully overexpressed in CaOV3 and SKOV3 cells. (B,C) PAK2 was successfully overexpressed in CaOV3 and SKOV3 cells. (D–G) PAK2 overexpression distinctly counteracted RP11-499E18.1 overexpression-triggered suppressing effects on the proliferation, colony formation, and migration of CaOV3 and SKOV3 cells. PAK2, P21 (RAC1) activated kinase 2. ^###p < 0.001, ns, no significance.