Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 21;9:697831. doi: 10.3389/fcell.2021.697831

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Yang, Peng and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Knockdown of SOX2 notably reversed PAK2 overexpression-triggered tumor-promoting effects. (A) PAK2 overexpression notably have no notable influence on the expression of SOX2, but obviously increased the expression of p-SOX2. (B) PAK2 overexpression promoted the nuclear translocation of SOX2. (C–F) Knockdown of SOX2 obviously reversed PAK2 overexpression-induced augmenting effects on the proliferation, colony formation, and migration of CaOV3 and SKOV3 cells. (G) PAK2 overexpression obviously decreased the expression of EMT-associated E-cadherin, and increased the expression of Vimentin. Knockdown of SOX2 notably counteracted PAK2 overexpression-induced effects. PAK2, P21 (RAC1) activated kinase 2; SOX2, SRY-box transcription factor 2; EMT, epithelial–mesenchymal transition. ^##p < 0.01.