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. 2021 Sep 21;11:711207. doi: 10.3389/fonc.2021.711207

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Copyright © 2021 Jiang, Li, He, Wei, Yan and Wen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HIF1A as a potential IGF2BP3 target was highly expressed in SC. (A) Venn analysis (http://jvenn.toulouse.inra.fr/app/example.html) for genes in Supplementary Tables 1, 2, and 3. List 1: Starbase-predicted mRNAs that could bind with IGF2BP3. List 2: m6A2Target-analyzed genes that could be positively regulated by IGF2BP3. List 3: GEPIA-analyzed differentially expressed genes in SC tissues versus normal tissues. (B) Expression analysis of HIF1A in 408 cases of SC tumor samples and 211 cases of normal samples by the GEPIA website (http://gepia.cancer-pku.cn/). (C) Expression analysis of HIF1A in primary SC tumor tissues (n=415) and normal tissues (n=34) by the UALCAN database (http://ualcan.path.uab.edu/). (D) Expression level of HIF1A in 6 pairs of SC tumor tissues and adjacent normal tissues was determined by western blot assay. ^* p < 0.05.