Table 4.

Analysis of GC haplotypes for the antenatal and cord blood vitamin D genome-wide association analysis (GWAS).

Haplotype and definition			Antenatal vitamin D (N=827)a				Cord blood vitamin D (N=656)b				Published values for Jorde and Grimnes (2015)
Haplotype	rs4588c	rs7041c	N	mean±SD	Β	p	N	mean±SD	Β	p	N	mean±SD
1s/1s	GG	CC	114	86.7±24.8	ref	ref	99	35.5±9.2	ref	ref	3,621	55.4±16.8
1s/1f	GG	AC	210	86.5±24.8	−1	0.74	147	35.9±8.4	0.43	0.72	2,456	53.3±17.2
1f/1f	GG	AA	139	85.6±24.9	−1.78	0.59	126	35.7±9.1	0.23	0.85	510	52.2±16.8
1s/2	GT	AC	150	80.1±24.8	−7.45	0.015	113	33.2±8.7	−2.36	0.052	3,315	50.3±15.6
1f/2	GT	AA	163	76.5±20.4	−11.3	3.4×10−4	127	32.6±8.6	−2.97	0.016	1,104	50.5±16.3
2/2	TT	AA	51	69.7±20.9	−18.3	1.6×10−5	44	28.9±7.1	−6.67	3.7×10−5	698	46.9±15.1

^aMutually adjusted for ethnicity, consumption of vitamin D containing supplements and age at recruitment. The mean±SD column is after adjusting for these covariates. The B and value of p are from the estimates from the linear regression.

^bMutually adjusted for antenatal vitamin D levels and ethnicity. The mean±SD column is after adjusting for these covariates. The B and value of p are from the estimates from the linear regression.

^cAll of the alleles are reported on the positive strand.