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. 2021 Sep 21;9:744838. doi: 10.3389/fcell.2021.744838

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Copyright © 2021 Dong, Zhang, Liu, Xu, Chang, Chen, Pan, Hu, Wang and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Opa1 knockdown or overexpression respectively aggravates or partially rescues cisplatin induced hair cell damage in organotypic cochlear cultures. (A) Representative confocal images of the apical, middle, and basal regions of organotypic cochlear cultures transfected with siOpa1 or Opa1 and treated with 60 μM cisplatin. Hair cells are indicated by MYO7A staining (red) and nuclei are indicated by DAPI staining (blue). (B,C) Quantification of IHCs (B) and OHCs (C) in the apical, middle, and basal turns. N = 3–5 per groups. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001 (two-way ANOVA).