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. 2021 Sep 21;11:715396. doi: 10.3389/fcimb.2021.715396

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Copyright © 2021 Li, Epperly, Barreto, Greenberger and Methé

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GSAA Experiment Kaplan-Meier Plot. The KM plot for the 2 drug GSAA experiment demonstrates the survival rate of the 4 treatment combinations. Day 0 and 1 are baseline and post-irradiation, respectively. Note the first necessary sacrifice occurs after day 9, and survivors past day 24 were assumed to have recovered from the TBI. Neither treatment nor control, guaranteed full survival or recovery. The treatment groups receiving G-CSF outperformed those with JP4-039 or control. The JP4-039 treatment was not statistically significantly different from the control with a p-value = 0.346.