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. 2021 Sep 21;11:715396. doi: 10.3389/fcimb.2021.715396

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Copyright © 2021 Li, Epperly, Barreto, Greenberger and Methé

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IPCD Experiment Kaplan-Meier Plot. The KM plot for the 3 drug IPCD experiment illustrates the survival rates of the 8 treatment combinations. Day 0 and 1 are baseline and post-irradiation, respectively. The critical period between days 9 to 24, when any mice requiring euthanasia were sacrificed, match the time period in the GSAA experiment. The single drug treatments performed as well as the control with a 26.67% survival rate. The top performing combinations included both JP4-039 and baicalein. With and without necrostatin-1 (p-value = 0.0359, and p-value = 0.0995, respectively), these treatment groups were statistically significantly different from the control, with survival rates of 60% versus 26.7%.