Table 1.
Description of the study participants at baseline.
| Total group (n = 173) | Amyloid negative (83%) | Amyloid positive (17%) | P-value | |
|---|---|---|---|---|
| Demographics and clinical characteristics | ||||
| Age | 70.3 ± 7.4 | 69.3 | 74.1 | 0.010 |
| Sex, n females (%) | 100 (57.8%) | 78 (55.3%) | 19 (65.5%) | 0.421 |
| Education (years) | 11.6 ± 2.7 | 11.7 ± 2.6 | 11.1 ± 3.4 | 0.489 |
| MMSE | 29.0 ± 1.2 | 29.1 ± 1.1 | 28.6 ± 1.5 | 0.117 |
| Neuropsychological tests | ||||
| RAVLT immediate recall (n = 164) | 42.1 ± 9.0 | 42.8 ± 9.1 | 38.8 ± 7.8 | 0.06 |
| RAVLT delayed recall (n = 164) | 8.4 ± 2.8 | 8.5 ± 2.9 | 7.8 ± 2.2 | 0.112 |
| RCF recall 3 min (n = 165) | 18.8 ± 5.3 | 19.5 ± 5.3 | 15.6 ± 4.1 | <0.001 |
| RCF recall 20 min (n = 163) | 18.7 ± 4.9 | 19.2 ± 4.8 | 16.0 ± 4.2 | 0.038 |
| FNAME delayed recall subscore names (n = 150) | 20.1 ± 9.9 | 21.0 ± 10.2 | 15.6 ± 6.7 | 0.397 |
| FNAME delayed recall subscore occupation (n = 150) | 33.2 ± 8.9 | 33.9 ± 8.8 | 29.8 ± 9.1 | 0.163 |
| MRI imaging characteristics | ||||
| GM volume (cm3) | 72693 ± 8574 | 73260 ± 7403 | 72262 ± 4352 | 0.275 |
| Log FC in the DMN | 1.36 ± 0.14 | 1.36 ± 0.13 | 1.34 ± 0.13 | 0.209 |
| Amyloid status | ||||
| CSF Aß 42/40 ratio (pg/ml) (n = 109) | 0.10 ± 0.03 | 0.11 ± 0.02 | 0.05 ± 0.02 | <0.001 |
| PET Global DVR (n = 167) | 1.03 ± 0.13 | 0.99 ± 0.08 | 1.20 ± 0.16 | <0.001 |
| PET DVR in the PCC (n = 167) | 1.36 ± 0.19 | 1.30 ± 0.11 | 1.64 ± 0.24 | <0.001 |
| PET DVR in the precuneus (n = 167) | 1.21 ± 0.16 | 1.17 ± 0.09 | 1.44 ± 0.22 | <0.001 |
| PET DVR in the MOF cortex (n = 167) | 1.21 ± 0.18 | 1.15 ± 0.08 | 1.50 ± 0.23 | <0.001 |
Data are presented as mean ± SD for continuous variables, or number (percentage) for dichotomous variables.
Aß, amyloid ß; DMN, default-mode network; DVR, distribution volume ratio; FC, functional connectivity, FNAME, face-name associated memory examination; GM, gray matter; MMSE, mini-mental state examination; MOF, medio-orbitofrontal cortex; PCC, posterior cingulate cortex; RAVLT, Rey auditory verbal learning test; RCF, Rey complex figure.