TABLE 4.

siRNA and mRNA for the treatment of hepatic fibrosis.

Anti-fibrotic mechanism	Target pathway/protein	Research state	NCT number	References
siRNA	TGF-β1	Preclinical study	–	Cheng et al., 2009
	HDAC2	Preclinical study	–	Li et al., 2016
	β-catenin	Preclinical study	–	Ge et al., 2014
	CB1	Preclinical study	–	Chen et al., 2012
miRNA	Miravirsen(miR-122)	Phase 2a	NCT01200420	Zeng et al., 2015
	miR-101	Preclinical study	–	Lei et al., 2019
	miR-29b	Preclinical study	–	Wang et al., 2015