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(A) Quantification of caudate volume loss in the TRACK-HD study showed near monotonic change from baseline to 12- and 24-month follow-up across the disease spectrum, with the rate of change increasing after clinical motor diagnosis (3). (B) Change in caudate volume with CAP score from TRACK-HD data (8). (C) Longer follow-up in the IMAGE-HD study also showed a greater degree of longitudinal change in the caudate volume in individuals with a clinical motor diagnosis (20).
