Table 1.

Cross-sectional partial correlations between regional brain volumes and clinical outcome measures in individuals prior to clinical motor diagnosis, after removing the effect of age, sex, and years of education, obtained from an analysis of the PREDICT-HD study (39).

	Motor ( N = 504)						Cognitive ( N = 486)					Functional ( N = 516)
	Speeded tapping	UHDRS total motor	UHDRS oculomotor	UHDRS bradykinesia	UHDRS chorea	UHDRS dystonia	Symbol-digit modalities	Hopkins verbal learning	Emotion recognition	Self-paced timing	Letter-number sequencing	Total functional capacity	Functional assessment scale
Putamen	−0.42	−0.27	−0.18	−0.22	−0.22		0.33	0.23	0.31	0.32	0.15
Caudate	−0.42	−0.29	−0.2	−0.25	−0.21		0.31	0.33	0.33	0.32	0.2
Globus pallidus	−0.36	−0.3	−0.2	−0.24	−0.27		0.35	0.29	0.33	0.34	0.18
Thalamus	−0.14						0.12
Nucleus accumbens	−0.2	−0.14	−0.13				0.13		0.15
Hippocampus
Frontal white	−0.15	−0.15	−0.12	−0.16
Parietal white	−0.21	−0.12		−0.17			0.23		0.16	0.18	0.13
Occipital white				−0.13			0.19		0.13
Temporal white		−0.13		−0.17			0.12
Frontal gray
Parietal gray
Occipital gray
Frontal gray

Only correlations that remained statistically significant following false discovery rate multiplicity correction are shown. The directionality of the associations was such that smaller tissue volumes were associated with greater impairment (higher scores on motor tasks, lower scores on cognitive tasks). Significant positive correlations are highlighted in a red color scale, significant negative correlations in a blue color scale, and darker shades are associated with stronger correlation coefficients.