Table 1.

Overview of circRNAs in neurodevelopmental impairments.

Neuro developmental impairments	Disease or injury model	Specific circRNAs	Corresponding miRNAs/RBPs	Possible biological process	Possible signaling pathway	References
Intelligence	Human prenatal neocortex Long-term potentiation and long-term memory impairments in adult mice model	circSATB2	–	Neuronal development	BDNF signaling	Chen et al. (37), Jaitner et al. (58)
Cognition	BTBR mice model	circCdh9	–	Neuronal development and maintenance	Activity-dependent signaling pathways	Gasparini et al. (17)
	Genetic knockdown mice model	circHomer1α	HuD	Neuronal excitability and synaptic plasticity	–	Zimmermanet al. (44)
	Transgenic Alzheimer's disease mouse model Human blood samples	circHDAC9	miR-138	Synaptic plasticity	Sirt1 pathway	Lu et al. (59)
Behavior	Middle cerebral artery occlusion in mouse model	circTLK1	miR-335-3p	Neuronal injury and plasticity	The expression of TIPARP	Wu et al. (40)
Epilepsy	TLE blood samples	circ-EFCAB2	miR-485-5p	Synaptic plasticity	Calcium channel	Li et al. (60)
		circ-DROSHA	miR-1252-5p	Inhibition of neuron cdepolarization	The decrease of ATP1A2
	TLE rat model	circ_Arhgap4	miR-6328	Synaptic plasticity	Dopamine receptor D2	Gomes-Duarte et al. (61)

BDNF, brain-derived neurotrophic factor; Sirt1, sirtuin-1; TIPARP, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase; TLE, temporal lobe epilepsy; ATP1A2, alpha 2 subunit of Na+, K+-ATPase.