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. 2021 Sep 21;12:756924. doi: 10.3389/fphar.2021.756924

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Copyright © 2021 Wang, Ma, Fu, Gong, Zhang, Zhou and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PHI protected intestinal epithelial barrier breakdown induced by CCl₄. (A) HE staining of ileum ( × 40 and × 200) (B) Villus height. (C) Villus width. (D) Crypt depth. Data was expressed as the mean ± SD (n = 6). ^### p < 0.001 represent compared with solvent control group. **p < 0.01, ***p < 0.001 represent compared with CCl₄ group. n. s indicates no significant.