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. 2021 Sep 21;12:756924. doi: 10.3389/fphar.2021.756924

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Copyright © 2021 Wang, Ma, Fu, Gong, Zhang, Zhou and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PHI modulates the composition of gut microbiota. (A) The alpha diversity of each group was obtained using the Chao1 index, Shannon index and Simpson index. (B) PCoA of gut microbiota. (C) The relative abundance of bacteria at the phylum level. (D) Representative histogram of the gut microbiota at the phylum level. (E) Bacteroides to Firmicutes ratio. A: Normal control; B: Solvent control; C: CCl₄; D: CCl₄ + 10 mg/kg PHI; E: CCl₄ + 20 mg/ kg PHI; F: CCl₄ + 40 mg/ kg PHI. Data was expressed as the mean ± SD (n = 6). ^# p < 0.05, ^## p < 0.01 represent compared with solvent control group. *p < 0.05, **p < 0.01 represent compared with CCl₄ group. n. s indicates no significant.