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. 2021 Sep 21;12:732002. doi: 10.3389/fgene.2021.732002

FIGURE 1.

FIGURE 1

Additive effects between CNTNAP2 and LRRC4C in patient IGGAC13. (A) Screenshots of chromosome 11 region overlapping the deletion of patient IGGAC13 (red bar IGGAC13, chr11:40,303,114-40,694,847). Decipher CNVs (a: deletion in patient 282991; b: deletion in patient 276911). (B) Screenshots of chromosome 7 region overlapping the deletion of patient IGGAC13 (red bar IGGAC13, chr7:146,464,283-146,532,437). Decipher CNVs (a: deletion in patient 319381; b: intragenic duplication in patient 255117; c: deletion in patient 250646). Only Decipher patients with additional CNVs that overlap neurodevelopmental genes were selected and reported in the figure. (C) The network depicts the protein-protein interactions (grey lines), experimentally determined interaction (red lines) and co-expression (bold black lines) of the KEGG pathway “Cell adhesion molecule,” revealed by STRING analysis on the basis of enrichment obtained with GeneCodis4, and visualized by Cytoscape tool. The Figure shows the clustering of the candidate genes with other known NDD genes. In yellow the interacting molecules directly linking the two candidate genes to each other.