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. 2021 Sep 21;12:741801. doi: 10.3389/fphar.2021.741801

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Copyright © 2021 Yu, Lin, Yang, Wei, Chen, Liu, Zhong, Chen, Pei and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of hirudin on renal histopathological alterations in unilateral ureteral obstruction (UUO)-induced renal interstitial fibrosis (RIF) rats. (A) HE staining showed that hirudin significantly reduced tubular dilatation or atrophy, interstitial fibrosis and inflammatory cell infiltration in the UUO rats (magnification×200). (B) Masson trichrome staining showed that hirudin significantly reduced renal tubulointerstitial damage and total collagen deposition in UUO rats. (magnification×400).