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. 2021 Sep 21;12:741801. doi: 10.3389/fphar.2021.741801

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Copyright © 2021 Yu, Lin, Yang, Wei, Chen, Liu, Zhong, Chen, Pei and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of hirudin on inhibition of FN, COL1, COL3 and α-SMA induced by unilateral ureteral obstruction (UUO). (A) Effect of hirudin on FN, COL1 and COL3 in UUO kidney tissues, as determined by Western blot. (B) Effect of hirudin on FN, COL1 and COL3 in UUO kidney tissues, according to the results of Western blot. (C) Effect of hirudin on α-SMA in UUO kidney tissues, as determined by Immunohistochemical staining (magnification ×200). (D) Effect of hirudin on α-SMA in UUO kidney tissues, according to the results of Immunohistochemical staining. (E) Effect of hirudin on FN, COL1 and COL3 in UUO kidney tissues, according to the results of RT-qPCR. Data are expressed as mean ± SD for six rats per group. ^∗∗ indicates p < 0.01and ^∗ indicates p < 0.05.