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. 2021 Sep 21;12:741801. doi: 10.3389/fphar.2021.741801

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Copyright © 2021 Yu, Lin, Yang, Wei, Chen, Liu, Zhong, Chen, Pei and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hirudin inhibited the PI3K/Akt signaling pathway in UUO kidneys. (A) Effect of hirudin on PI3K in UUO kidney tissues, as determined by immunohistochemical staining. (magnification ×400) (B) Hirudin reduced the PI3K positive expression area in UUO kidneys, according to the results of immunohistochemical staining. (C) Effect of hirudin on p-Akt and mTOR in UUO kidney tissues, as determined by Western blot. (D) Effect of hirudin on p-Akt and mTOR in UUO kidney tissues, according to the results of Western blot. (E) Effect of hirudin on PI3K, p-Akt and mTOR in UUO kidney tissues, according to the results of RT-qPCR. Data are expressed as mean ± SD for six rats per group. ^∗∗ indicates p < 0.01and ^∗ indicates p < 0.05.