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. 2021 Sep 21;12:741801. doi: 10.3389/fphar.2021.741801

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Copyright © 2021 Yu, Lin, Yang, Wei, Chen, Liu, Zhong, Chen, Pei and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hirudin attenuates renal interstitial fibrosis in TGF-β1 induced NRK-52E cells. (A) CCK-8 assay showed that the ability of cell viability was decreased in NRK-52E cells by treatment with hirudin. (B) Effect of hirudin on COL1, FN and E-Cad in NRK-52E cells, as determined by Western blot. (C) Effect of hirudin on COL1, FN and E-Cad in NRK-52E cells, according to the results of Western blot. (D) Effect of hirudin on COL1, FN and E-Cad in NRK-52E cells, according to the results of RT-qPCR. Data are expressed as mean ± SD (n = 3 for each group). ∗∗ indicates p < 0.01 and ∗ indicates p < 0.05.