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. 2021 Sep 21;12:741801. doi: 10.3389/fphar.2021.741801

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Copyright © 2021 Yu, Lin, Yang, Wei, Chen, Liu, Zhong, Chen, Pei and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hirudin inhibits the PI3K/Akt signaling pathway in TGF-β1-treated NRK-52E cells. (A) Effect of hirudin on PI3K, p-Akt, mTOR, Beclin1 and P62 in TGF-β1-treated NRK-52E cells, as determined by Western blot. (B) Effect of hirudin on PI3K, p-Akt, mTOR, Beclin1 and P62 in TGF-β1-treated NRK-52E cells, according to the results of Western blot. (C) Effect of wortmannin on PI3K, p-Akt, mTOR in TGF-β1-treated NRK-52E cells, as determined by Western blot.(D) Effect of wortmannin on PI3K, p-Akt, mTOR in TGF-β1-treated NRK-52E cells, according to the results of Western blot. Data are expressed as mean ± SD (n = 3 for each group). ∗∗ indicates p < 0.01 and ∗ indicates p < 0.05.