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. 2021 Sep 21;11:753690. doi: 10.3389/fonc.2021.753690

Table 2.

Univariate and multivariate Cox regression analyses of factors predictive of progression-free survival in type 2 PRCC patients.

Variable Univariate analysis Multivariate analysis
HR 95% CI p HR 95% CI p
Gender (male vs. female) 1.111 0.472–2.616 0.809
Age (>55 vs. ≤55) 1.582 0.728–3.437 0.246
Tumor location (left vs. right) 1.505 0.712–3.182 0.285
Tumor size (>5.8 cm vs. ≤5.8 cm) 2.617 1.205–5.683 0.015 1.032 0.450–2.364 0.941
Surgical procedures (RN vs. PN) 4.877 1.472–16.160 0.010 2.562 0.713–9.210 0.149
T stage (III/IV vs. I/II) 6.692 3.177–14.097 <0.001 3.879 1.559–9.649 0.004
WHO/ISUP grade (G3/4 vs. G1/2) 8.546 2.570–28.416 <0.001 5.275 1.500–18.551 0.010
Microvascular invasion (yes vs. no) 4.138 1.820–9.408 0.001 1.356 0.496–3.709 0.553
Tumor necrosis (yes vs. no) 1.095 0.495–2.421 0.823
Sarcomatoid differentiation (yes vs. no) 2.186 0.296–16.171 0.444

PRCC, papillary renal cell carcinoma; RN, radical nephrectomy; PN, partial nephrectomy; WHO/ISUP, WHO International Society of Urological Pathology.