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. 2021 Sep 21;8:715215. doi: 10.3389/fmolb.2021.715215

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Copyright © 2021 Barreto, Baptista , Preto, Silvério, Melo and Moreira.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Common interaction binding motifs in the OR family. Receptors and partners are both represented as surface. 3D structures correspond to DOR-G_i1, KOR-G_ssh, DOR-G_q and KOR-G₁₂ (from top to bottom). Residues reported in Figure 2 were colored by their subdomain using the color scheme available at the sequence alignment on the webserver. Receptor: TM2 - yellow; TM3 - light green; ICL2 - dark green, TM4 - lime; TM5 - light blue; ICL3 - dark blue; TM6 - blue, TM7 - purple; H8 - red. Partner: HN - light green, hns1 - dark teal; S3 - yellow; h4s6 - light blue; H5 - dark grey.