Figure EV5. Comparison of PTX effects on protein changes to the dynamics published in Dorrbaum et al (2020).

Pearson's correlation of significantly changing proteins (FDR < 0.5) upon PTX treatment in both compartments to protein dynamics determined by a whole cell SILAC experiment subsequent bicuculline treatment (Dorrbaum et al, 2020). The statistical significance of Pearson correlations was calculated in the standard fashion, i.e. by testing against a null hypothesis of r = 0 using a t‐distribution with N‐2 degrees of freedom. Regression lines indicate fitted linear models, with the light grey shaded areas depicting the 95% confidence interval. Proteins significantly downregulated in the processes compartment with a logFC of less than −0.5 are highlighted in the processes panel.

1. Correlation with changes in protein abundance as determined by Dörrbaum and colleagues upon bicuculline treatment over the time period of 7 days (three time points of protein collection).
2. Correlation with changes of the nascent (newly synthesized) proteome over the 7 days' time course.
3. Correlation with changes of the pre‐existing proteome over the 7 days' time course.
4. Correlation with changes of the nascent proteome seen by Dorrbaum et al (2020) after the time point of 1 day.
5. Correlation with changes of the pre‐existing proteome at the 1‐day time point.