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Genetically encoded sensors. A, Degron-FP fusion; (B) FP as recognition element; (C) roGFP2-Orp1 and (D) HyPer sensors; (E) ratiometric FRET-based sensors consisting of two FPs and a recognition element; (F) intensiometric cpFP-recognition element fusion; and (G) ratiometric Matryoshka sensor with cpFP and nested reference FP.
