Table 1.
Prescreening tool cohort: baseline differences between pregnant patients at high risk for preeclampsia who presented for 12-week ultrasound who were or were not recommended aspirin therapy
| Total (n ¼ 156) | No aspirin recommended n ¼ 40 (25.6%) | Aspirin recommended n ¼ 116 (74.4%) | p-Value | Adjusted OR | |
|---|---|---|---|---|---|
| Baseline demographics | |||||
| Maternal age (y) | 31.9 ± 5.9 | 30.9 ± 5.9 | 32.2 ± 5.9 | 0.23 | NS |
| Nulliparity | 44 (28.2) | 17 (42.5) | 27 (23.3) | 0.02a | NS |
| Race | 0.04a | NS | |||
| African–American | 95 (61.3%) | 19 (47.5%) | 76 (66.1%) | ||
| Caucasian | 27 (17.4%) | 12 (30.0%) | 15 (13.0%) | ||
| Asian | 11 (7.1%) | 4 (10.0%) | 7 (6.1%) | ||
| Latino/Hispanic | 16 (10.3%) | 3 (7.5%) | 13 (11.3%) | ||
| Other/unknown | 6 (3.8%) | 2 (5.0%) | 4 (3.5%) | ||
| Body mass index (kg/m2) | 33.1 ± 8.4 | 32.4 ± 9.2 | 33.4 ± 8.1 | 0.537 | NS |
| Current smoker | 13 (8.3%) | 3 (7.5%) | 10 (8.6%) | >0.999 | |
| Alcohol use in pregnancy | 3 (1.9%) | 1 (2.6%) | 2 (1.7%) | >0.999 | |
| Illicit opiate/cocaine use | 4 (2.6%) | 1 (2.5%) | 3 (2.6%) | >0.999 | |
| Preeclampsia risk factor | |||||
| Prior mild preeclampsia | 32 (20.5%) | 2 (5.0%) | 30 (25.9%) | 0.005a | 10.15 (2.94–53.79) |
| Prior severe preeclampsia | 19 (12.2%) | 0 (0%) | 19 (16.4%) | 0.004a | 29.02 (3.62–3,768.02) |
| Chronic hypertension | 89 (57.1%) | 17 (42.5%) | 72 (62.1%) | 0.041a | 3.48 (1.57–7.96) |
| Pregestational diabetes | 43 (27.6%) | 16 (40.0%) | 27 (23.3%) | 0.063 | NS |
| Chronic kidney disease | 11 (7.1%) | 5 (12.5%) | 6 (5.2%) | 0.153 | NS |
| Systemic lupus erythematous | 5 (3.2%) | 1 (2.5%) | 4 (3.4%) | 0.999 | NS |
| Antiphospholipid antibody syndrome | 3 (1.9%) | 0 (0.0%) | 3 (2.6%) | 0.570 | NS |
| Multifetal gestation | 9 (5.8%) | 4 (10.0%) | 5 (4.3%) | 0.236 | NS |
Abbreviations: OR, odds ratio; NS, not significant.
Note: Data presented as n (%) or mean ± standard deviation. No missing data.
a
Indicates significance, p < 0.05. Adjusted OR represents multiple logistic regression analysis with backward stepwise variable selection for factors associated with being recommended aspirin. NS represents nonsignificant (95% confidence interval includes 1.0).