Table 1.

Selected large multisite trials funded by PCORI^a.

Principal investigator	Study title	Summary	PCORI contract number	ClinicalTrials.gov number
AWA	Improving Specialty-Care Delivery in Chronic Skin Diseases	This study evaluated an innovative CCHb model where patients and primary care providers could access dermatologists on the web directly and asynchronously via a pragmatic RCTc to test whether a CCH model results in equivalent improvements in disease severity, quality of life, and mental health, and whether the model provides better access to specialty care, compared with usual in-person care for psoriasis management.	IHS-071502-IC	NCT02358135
TRC	Using Telehealth to Deliver Developmental, Behavioral, and Mental Health Services in Primary Care Settings for Children in Underserved Areas	Using community-engaged research principles, FQHCd (n=6 sites) and CHMCse (n=2 sites) designed a telehealth-based intervention to improve the referral system for children being referred to specialty mental health care from primary care. We conducted an RCT involving 342 children, aged 5-12 years, with mental health concerns to receive either a routine referral or the new telehealth-enabled referral system.	IH-12-11-4168-IC	NCT02396576
ERD	Connect.Parkinson	Connect.Parkinson assessed the feasibility, value, and benefits of telemedicine visits with a specialist for individuals with Parkinson disease (n=200) through randomization to usual care or their routine care enhanced by video visits with a Parkinson specialist in approximately 20 US states.	AD-12-11-4701	NCT02038959
KJG	C3FITf Stroke Care Trial	C3FIT uses team-based, enhanced collaboration to follow patients from presentation at the Emergency Department through 12 months post discharge to compare joint commission-certified stroke care with an Integrated Stroke Practice Unit care model that uses nurse and lay health educator care teams to visit patients and caregivers at home or in rehabilitation or skilled nursing facilities to assess function and quality of life using telehealth technology for patients at 18 US clinical sites.	PCS-2017C3-9081	NCT04000971
HQN, Mularski RA	Noninferiority Comparative Effectiveness Trial of Home-Based Palliative Care (HomePal) Trial	HomePal is a CERg comparing two models of home-based palliative care, standard approach with nurses and physicians making home visits versus nurses in patients’ home facilitating remote physician consults.	PLC-1609-36108	NCT03694431
DRS	SUMMITh Trial	SUMMIT examines whether psychotherapy delivered via telemedicine is as effective as in-person sessions for perinatal populations in Toronto, Canada; Chapel Hill, North Carolina; and Chicago, Illinois.	PCS-2018C1-10621	NCT04153864
ES	Specialty Medical Homes to Improve Outcomes for Patients With IBDi and Behavioral Health Conditions Trial	This trial compares traditional face-to-face delivered to telemedicine delivered team-based care within a subspecialty medical home integrating behavioral and medical care for patients with IBD in Pittsburgh, Pennsylvania, New York City, New York, and Cleveland, Ohio.	IHS-2017C3-8930	NCT03985800

^aPCORI: Patient-Centered Outcomes Research Institute.

^bCCH: Collaborative Connected Health.

^cRCT: randomized controlled trial.

^dFQHC: federally qualified health center.

^eCHMC: community mental health clinic.

^fC3FIT: Co-ordinated, Collaborative, Comprehensive, Family-based, Integrated, Technology-Enabled Care.

^gCER: community-engaged research.

^hSUMMIT: Scaling Up Maternal Mental Healthcare by Increasing Access to Treatments.

ⁱIBD: inflammatory bowel disease.