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. Author manuscript; available in PMC: 2021 Oct 5.
Published in final edited form as: Sci Signal. 2021 Mar 9;14(673):eabc5763. doi: 10.1126/scisignal.abc5763

Fig 2. Effector-memory T cell subsets are the predominant subsets that show IL-1β-induced increases in p-NF-κB and p-p38.

Fig 2.

UMAP and Leiden clustering using the cell surface markers shown in C were performed on vehicle- and IL-1β-treated CD3+ T cells. (A) The 12 T cell clusters identified were superimposed on the UMAP. (B) Frequency of T cell clusters and inter-individual variations between donors. (C) Heatmap showing the median expression of surface markers across all 12 T cell clusters. The color in the heatmap represents the median of the arcsinh for each subset with 0–1 transformed marker expression. The dendrogram represents the hierarchical similarity for subsets. (D and E) Frequency of p-NF-κB+ cells and p-p38+ cells within each cluster in the vehicle-treated (–) and IL-1β-stimulated (+) samples. Data shown are mean ± SEM. N=3 donors for A-E.