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(A) Affinity and selectivity of leading molecules 25 (DW34) and 26. (B) Selectivity of DW34 screened at 500 nM against a panel of 32 bromodomains by BROMOscan. Residual activity based on percent control is labeled in red circles. Sizes and cutoffs have been determined by Eurofins. Bromodomains not tested are shown in light gray.
