Table 4.

Microsomal Stabilities of Selected Molecules

compound	k	t1/2 (min)	CLint (μL/min/mg protein)	fu (fraction unbound)
UMN627	0.013 ± 0.001	54.2 ± 6.0	25.6 ± 2.5	0.080 ± 0.01
1	0.015 ± 0.002	46.7 ± 5.4	29.7 ± 3.1	0.13 ± 0.01
13	0.0090 ± 0.001	81.1 ± 10	17.1 ± 1.9	0.12 ± 0.02
16	0.020 ± 0.002	34.2 ± 3.0	40.5 ± 3.3	0.11 ± 0.03
17	0.020 ± 0.001	35.0 ± 2.4	39.5 ± 2.5	0.090 ± 0.02
DW34	0.0060 ± 0.001	117 ± 15	11.9 ± 1.4	0.14 ± 0.01
26	0.0083 ± 0.001	83.5 ± 6.6	16.6 ± 1.2	0.13 ± 0.01