Skip to main content
. Author manuscript; available in PMC: 2022 Jul 22.
Published in final edited form as: J Med Chem. 2021 Jul 8;64(14):10497–10511. doi: 10.1021/acs.jmedchem.1c00933

Table 5.

Drug-like Properties of DW34 and UMN627

compound DW34 UMN627
MW 434.59 535.62
clogP  3.78  3.32
no. aromatic rings  3  4
LEa  0.331  0.189
LLEb  4.14  2.17
a

Ligand efficiency (LE) = ΔG/number of heavy atoms, reported in kcal/mol per heavy atom.

b

Lipophilic ligand efficiency (LLE) = calculated as pKd – clogP.