Table 1. Model inputs.
| Parameter | Description and value |
|---|---|
| Transmission
intensity |
More than half of the population (54.5%) fell in the moderate intensity category, 42.2% in the high intensity
category and only 3.4% were in the low intensity category. Assumed fixed seasonal 23 |
| Access to case
management |
38% 24 |
| Bed net coverage | 82% own at least one bed net 24 |
| Vaccine efficacy | Clinical malaria 46% (95% CI 42% to 50%)
Severe malaria 34% (95% CI 15% to 48%) |
| Vaccine schedule | In Malawi, the first dose of the RTS,S/AS01 vaccine is expected to be administered to children at 5 months with
the second and third at one month intervals; the fourth dose is to be given 15–18 months after the third dose. |
| Vaccine coverage | The coverage of dose 3 of RTS,S was estimated at 75% of DTP3 coverage to account for the challenge in
reaching older children and also for the difference in schedule of the RTS,S with traditional vaccines such as the pentavalent vaccine. Dose 4 coverage of RTS,S was 80% of dose 3. |
| Cost of vaccination | Vaccine delivery costs USD 2.50
25 were estimated from the cost of delivering a single dose of the injectable DTP
vaccine. |
| Clinical malaria estimated costs USD | |
| Healthcare system | USD 8.02
20,
21. These include drugs, laboratory investigations, staff salaries and facility costs such as laundry,
kitchen, sanitation and security. |
| Household- direct | USD 1.21 20, 21. These include transportation costs, costs of consultations, drugs and diagnostics. |
| Household- indirect | USD 0.50 26. These are lost income by the carer attributable to the episode of disease |
| Severe malaria costs USD | |
| Healthcare system | USD 12.8
27 These include drugs, laboratory investigations, staff salaries and facility costs such as laundry,
kitchen, sanitation and security. |
| Household- direct | USD 14.1 21 These include transportation costs, costs of consultations, drugs and diagnostics. |
| Household- indirect | USD 4.13 21 These are lost income by the carer attributable to the episode of disease |
| Sequelae costs USD | |
| Healthcare system | USD 40.1
22 The neurological sequelae was adapted by the cost of treatment of malaria sequelae for the
Tanzanian health system |