Table 4. Results of Univariate Analysis (Mann–Whitney–Wilcoxon Test) for the Comparison of the Concentration Levels of Metabolite and Lipoproteins and Lipid Fractions in the Nondeceased (3M-nD) and Deceased (3M-D) Patients at 3 Months after AIS and Treatment with Rt-PA^a.

	patient groups
analyte	3M-nD	3M-D	P-value	FDR	Log2(FC)	trend
SubTrigl_HDL-4	3.25 ± 0.99	2.46 ± 1.09	0.001	0.1307	–0.40	↓
SubApoA1_HDL-4	69.23 ± 15.68	57.14 ± 17.01	0.0072	0.2418	–0.28	↓
phenylalanine	0.08 ± 0.03	0.10 ± 0.04	0.0087	0.2418	0.32	↑
lactic acid	2.3 ± 1.04	3.10 ± 0.89	0.0089	0.2418	0.43	↑
citric acid	0.15 ± 0.05	0.20 ± 0.08	0.0094	0.2418	0.38	↑
3-hydroxybutyrate	0.14 ± 0.16	0.26 ± 0.24	0.0129	0.2758	0.95	↑
SubPhosp_HDL-4	23.31 ± 6.37	18.48 ± 7.58	0.0207	0.3382	–0.34	↓
SubChol_VLDL-5	1.50 ± 0.70	1.27 ± 0.61	0.0253	0.3382	–0.24	↓
SubApoA2_HDL-4	18.45 ± 4.57	14.60 ± 5.40	0.0299	0.3382	–0.34	↓
SubChol_HDL-1	15.45 ± 7.06	17.99 ± 8.48	0.0307	0.3382	0.22	↑
SubPhosp_VLDL-5	1.79 ± 0.66	1.54 ± 0.38	0.0312	0.3382	–0.21	↓
LMF_ApoA2_HDL	30.81 ± 5.09	28.44 ± 5.54	0.0362	0.3382	–0.12	↓
SubFreeChol_HDL-2	1.79 ± 0.53	2.24 ± 0.56	0.0402	0.3382	0.32	↑
LMF_ApoA1_HDL	132.35 ± 24	121.96 ± 19.09	0.0414	0.3382	–0.12	↓
Apo-A2	30.14 ± 5.15	27.89 ± 6.12	0.0420	0.3382	–0.11	↓
acetone	0.12 ± 0.11	0.17 ± 0.12	0.0453	0.3382	0.44	↑
SubChol_HDL-4	18.37 ± 5.06	14.43 ± 7.81	0.0472	0.3382	–0.35	↓
SubChol_LDL-5	11.14 ± 7.86	6.66 ± 6.45	0.0482	0.3382	–0.74	↓

^aIn total, 128 blood analytes (18 metabolites and 110 lipoproteins/lipid fractions) were quantified using NMR. Only results for analytes for which the unadjusted raw P-value is <0.05 are reported: median (± MAD, median absolute deviation) in the two groups, raw P-value, adjusted P-value (FDR, Benjamini-Hochberg false discovery rate), Log₂ of the fold change, and trend (↓ decreasing trend, ↑ increasing trend referred to the 3M-D group). The concentrations of lipoproteins and lipid fractions are in mg/dL; the concentrations of metabolites are in mmol/L.