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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Trends Pharmacol Sci. 2020 Oct 1;41(11):851–867. doi: 10.1016/j.tips.2020.09.006

Figure 3. Schematic illustration S1P-induced sensory neurons excitability.

Figure 3.

Both S1PR1 and S1PR3 are expressed in sensory neurons and DRG, and their stimulation lead to neuronal depolarization through both the potentiation of TRPV1 channels and the activation of chloride currents. However, the underlying molecular mechanisms seem to be independent of each other. S1PR3 stimulation also activate TRPC and TRPA1 channels through distinct G-protein coupled pathways. Furthermore, S1P regulates nociception by modulating potassium currents through the blockade of KCNQ2/3 channels.