Table 2. ipso,α-Selective Asymmetric Aza-IEDDA between Diene 1 and Silyl Dienol Ether 2^ac.

^aAll of the reactions were performed on a 0.05 mmol scale of 1 in 0.3 mL of THF at rt. Diastereomeric ratios were determined by ¹H NMR of the crude mixture. Enantiomeric excesses were determined by SFC chromatography.

^bReaction was carried out in the presence of 0.3 mmol of 2c (mixture of isomers, 95(E):5(Z)).

^cReaction was carried out in the presence of 0.3 mmol of mixture of 2d (isomers, 95(E):5(Z)).