FIGURE 2.

Mechanisms of EBV infection of epithelial cell and B cell

Note. In the progress of EBV infection into epithelial cells, EBV glycoprotein gH/gL binds to integrin and NMHC‐IIA on the cell surface first. Then gH/gL/gB complex interacts with NRP1 and EphA2, triggering the conformational transition of gB. Lastly, the fusion loops of gB insert into the cell membrane and complete the fusion of EBV. At the first step of EBV infection into B cells, gp350 binds to its receptor protein CR2. After that, interaction between gp42 and HLA class II triggers the fusion progress. Eventually, gH/gL and postfusion gB drive the membrane fusion of EBV and B cell.