FIGURE 7.

Antitumor activity of 5T4 CAR‐T cells in subcutaneous tumor model. (A) On day 0, 5 × 10⁵ SKOV3‐luc cells were injected subcutaneously into the right back of B‐NDG mice. When the tumor volume was about 20 mm³, mice were treated with 5 × 10⁶ CAR‐T cells. The treatments were given every 2 days for a total of three times. We observed the growth of subcutaneous tumors by bioluminescence imaging weekly. (B) Tumor volume growth curve. We measured tumor volume with a Vernier caliper (the formula V = L × W ²/2, where L and W, respectively, represent the long and short diameters of the tumors) every 3 days. (C) Body weight curve of mice