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Liver tumors that developed in zebrafish as a result of exposure to chemical carcinogens are highly analogous to liver tumors in humans. Based on the molecular pathogenesis of human HCC, several transgenic zebrafish lines with different oncogenes have been established. Some of them exist on the platform that allow the identification of chemicals that have suppressor effects on the proliferation of human HCC cells. Image is reprinted from ref. 115
