Table 2.

Univariable- and Multivariable-Adjusted Association of Peak Troponin I Levels during Sepsis with Postsepsis Cardiovascular Events and Death

			Primary Analysis			Sensitivity Analyses
			Exclusion of All Patients With a Cardiovascular Diagnosis 5 yr before Sepsis Hospitalization (n = 14,046)			Exclusion of All Patients With Presepsis* or Intrasepsis Cardiovascular Diagnoses† (n = 6,874)
Model	Outcome	Troponin Category	n	HR (95% CI)	P Value	n	HR (95% CI)	P Value
Univariable models	Death from any cause	Normal, ⩽0.04 ng/ml	7,643	1.00 (reference)	—	4,483	1.00 (reference)	—
		Abnormal tertile 1, >0.04–0.09 ng/ml	2,135	1.18 (1.07, 1.30)	0.001	960	1.12 (0.96, 1.30)	0.14
		Abnormal tertile 2, >0.09–0.42 ng/ml	2,134	1.23 (1.12, 1.36)	<0.001	863	1.14 (0.97, 1.33)	0.11
		Abnormal tertile 3, >0.42 ng/ml	2,134	1.13 (1.02, 1.25)	0.02	568	0.96 (0.78, 1.17)	0.68
	Cardiovascular event	Normal, ⩽0.04 ng/ml	7,643	1.00 (reference)	—	4,483	1.00 (reference)	—
		Abnormal tertile 1, >0.04–0.09 ng/ml	2,135	1.71 (1.52, 1.94)	<0.001	960	1.44 (1.08, 1.91)	0.01
		Abnormal tertile 2, >0.09–0.42 ng/ml	2,134	1.77 (1.57, 2.00)	<0.001	863	1.35 (1.00, 1.83)	0.05
		Abnormal tertile 3, >0.42 ng/ml	2,134	2.02 (1.80, 2.27)	<0.001	568	1.69 (1.22, 2.35)	0.002
Multivariable models	Death from any cause	Normal, ⩽0.04 ng/ml	7,643	1.00 (reference)	—	4,483	1.00 (reference)	—
		Abnormal tertile 1, >0.04–0.09 ng/ml	2,135	1.04 (0.94, 1.15)	0.44	960	1.01 (0.87, 1.18)	0.90
		Abnormal tertile 2, >0.09–0.42 ng/ml	2,134	1.08 (0.97, 1.19)	0.14	863	1.09 (0.93, 1.27)	0.31
		Abnormal tertile 3, >0.42 ng/ml	2,134	1.06 (0.95, 1.18)	0.33	568	1.02 (0.83, 1.26)	0.86
	Cardiovascular event	Normal, ⩽0.04 ng/ml	7,643	1.00 (reference)	—	4,483	1.00 (reference)	—
		Abnormal tertile 1, >0.04–0.09 ng/ml	2,135	1.37 (1.20, 1.55)	<0.001	960	1.31 (0.98, 1.74)	0.07
		Abnormal tertile 2, >0.09–0.42 ng/ml	2,134	1.44 (1.27, 1.63)	<0.001	863	1.24 (0.91, 1.69)	0.18
		Abnormal tertile 3, >0.42 ng/ml	2,134	1.77 (1.56, 2.00)	<0.001	568	1.58 (1.11, 2.24)	0.01

Definition of abbreviations: CI = confidence interval; HR = hazard ratio.

Covariates: Presepsis factors include age, body mass index, sex, race, Charlson comorbidity score and history of diabetes mellitus, chronic kidney disease, dialysis, proteinuria, renal disease, chronic pulmonary disease, malignancy, metastatic solid tumor, organ transplant, acquired immunodeficiency disorder, mild liver disease, moderate/severe liver disease, peptic ulcer disease, rheumatologic disease, dementia, hemiplegia/paraplegia, smoking, antihypertensive use, antiplatelet use, statin use, and aspirin use. Intrasepsis factors include atrial fibrillation, maximum dose and proportion requiring vasopressor or inotropes, infection type, infection site, Laboratory Acute Physiology Score version 2, maximum Sequential Organ Failure Assessment score, lowest oxygen saturation, duration of and proportion requiring invasive and noninvasive ventilation, total volume and proportion requiring blood product transfusion, net fluid balance, admission season, and highest laboratory values for alanine aminotransferase, total bilirubin, creatinine, glucose, white blood cell count, band count, platelets, and lactate.

^*Strict exclusion criteria for presepsis cardiovascular diagnosis employed additional International Classification of Diseases 9/10 codes for coronary artery disease and peripheral artery disease detailed in Table E2.

^†Intrasepsis cardiovascular diagnosis was defined as any atherosclerotic cardiovascular disease, heart failure, or atrial fibrillation diagnosis by International Classification of Diseases 9/10 coding during sepsis hospitalization.