Figure 5.

Segmentation of necrotic granulomas demonstrating their connection with the airway. (A) Two-dimensional slice of tissue containing multiple granulomas. Necrotic granulomas (yellow), the vasculature (red), and the bronchus (green) are outlined. (B) Three-dimensional rendering of necrotic granulomas, the vasculature, and the bronchus (color coding is the same as in A) demonstrating the granuloma/vasculature/airway network (cyan) in decreasing transparency from A. Note how segmentation of the diseased tissue of similar radioopacity (dark area) surrounds and connects necrotic granulomas and airways, and also connects blood vessels to some extent, suggesting that the airways help shape the granuloma structure. See also Video E5 in the online supplement. Scale bars, 2 mm.