Table 1.

Differentially Expressed Genes in the Natural Killer–Cell Cluster

	Gene	IPF of Upper Lobe vs. Control		IPF of Lower Lobe vs. Control
		logFC	Adjusted P Value	logFC	Adjusted P Value
IFNγ	IFNG	0.961604	1.02 × 10−26	0.755063	0.428627
	IFNGR1	−0.64487	1.13 × 10−141	−0.37189	3.25 × 10−9
	IRF1	—	—	−0.28732	5.24 × 10−7
	IRF4	0.268594	1.51 × 10−42	—	—
	IRF8	0.784697	2.13 × 10−138	0.301498	5.57 × 10−5
Cytotoxicity	GNLY	0.550427	9.85 × 10−58	—	—
	GZMA	−0.32322	2.89 × 10−22	—	—
	GZMB	1.426721	2.18 × 10−90	−0.64957	0.011556
	GZMH	0.280219	1.29 × 10−10	—	—
	GZMK	−0.35484	3.16 × 10−45	0.51977	9.09 × 10−38
	GZMM	—	—	−0.28041	5.24 × 10−12
	PRF1	—	—	−0.27861	0.006536
ER stress	DNAJA1	—	—	0.288644	2.02 × 10−12
	DNAJB1	−0.30486	1	0.93242	1.31 × 10−43
	DUSP5	0.552546	1.87 × 10−100	—	—
	HSP90AA1	−0.27286	1	0.683977	2.80 × 10−32
	HSPA1A	−0.62515	7.68 × 10−47	1.253565	2.56 × 10−44
	HSPA1B	−0.35989	8.46 × 10−66	0.726816	1.02 × 10−21
	XBP1	—	—	−0.35802	5.26 × 10−38
	HSPB1	—	—	0.372697	4.72 × 10−39
	HSPH1	—	—	0.261661	2.59 × 10−18
	HSP90AB1	—	—	0.317723	3.64 × 10−23
MT zinc metabolism	MT1A	−0.26348	3.40 × 10−8	−0.29711	4.34 × 10−14
	MT1E	−0.3746	1.66 × 10−18	−0.39028	7.47 × 10−13
	MT1M	−0.30203	2.02 × 10−15	−0.32251	3.82 × 10−10
	MT1X	−0.67098	2.36 × 10−23	−0.55898	0.04864
	MT2A	—	—	−0.646	3.66 × 10−5

Definition of abbreviations: ER = endoplasmic reticulum; FC = fold change; IPF = idiopathic pulmonary fibrosis; MT = metallothionein.

The FC was calculated with the expression by the patients with IPF versus that by control subjects, and a Wilcoxon rank sum test was used to determine the P value. Cells without data mean that the statistics were not significant.