Table 10.
Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals of All Brain and Other Central Nervous System Tumors by Sitec and Sex, CBTRUS Statistical Report: U.S. Cancer Statistics – NPCR and SEER, 2014–2018
| Site | Total | Male | Female | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-Year Total | Annual Average | % of all tumors | Rate (95% CI) | 5-Year Total | Annual Average | % of all tumors | Rate (95% CI) | 5-Year Total | Annual Average | % of all tumors | Rate (95% CI) | |
| Frontal, temporal, parietal, and occipital lobes of the brain | 76,010 | 15,202 | 17.6% | 4.20 (4.17–4.23) | 42,464 | 8,493 | 23.7% | 4.96 (4.92–5.01) | 33,546 | 6,709 | 13.3% | 3.54 (3.50–3.58) |
| Frontal lobe | 33,535 | 6,707 | 7.8% | 1.88 (1.86–1.90) | 17,851 | 3,570 | 9.9% | 2.11 (2.08–2.14) | 15,684 | 3,137 | 6.2% | 1.68 (1.65–1.70) |
| Temporal lobe | 24,455 | 4,891 | 5.7% | 1.34 (1.33–1.36) | 14,631 | 2,926 | 8.2% | 1.70 (1.67–1.73) | 9,824 | 1,965 | 3.9% | 1.03 (1.01–1.05) |
| Parietal lobe | 14,226 | 2,845 | 3.3% | 0.77 (0.76–0.79) | 7,871 | 1,574 | 4.4% | 0.91 (0.89–0.93) | 6,355 | 1,271 | 2.5% | 0.65 (0.64–0.67) |
| Occipital lobe | 3,794 | 759 | 0.9% | 0.21 (0.20–0.21) | 2,111 | 422 | 1.2% | 0.25 (0.23–0.26) | 1,683 | 337 | 0.7% | 0.17 (0.17–0.18) |
| Cerebrum | 7,424 | 1,485 | 1.7% | 0.43 (0.42–0.44) | 3,986 | 797 | 2.2% | 0.48 (0.46–0.50) | 3,438 | 688 | 1.4% | 0.38 (0.37–0.40) |
| Ventricle | 4,127 | 825 | 1.0% | 0.25 (0.25–0.26) | 2,268 | 454 | 1.3% | 0.28 (0.27–0.29) | 1,859 | 372 | 0.7% | 0.23 (0.22–0.24) |
| Cerebellum | 9,401 | 1,880 | 2.2% | 0.59 (0.58–0.60) | 5,066 | 1,013 | 2.8% | 0.64 (0.63–0.66) | 4,335 | 867 | 1.7% | 0.53 (0.52–0.55) |
| Brain stem | 6,095 | 1,219 | 1.4% | 0.39 (0.38–0.40) | 3,259 | 652 | 1.8% | 0.41 (0.40–0.43) | 2,836 | 567 | 1.1% | 0.36 (0.35–0.38) |
| Other brain | 33,675 | 6,735 | 7.8% | 1.87 (1.85–1.89) | 17,860 | 3,572 | 9.9% | 2.13 (2.09–2.16) | 15,815 | 3,163 | 6.3% | 1.64 (1.62–1.67) |
| Overlapping lesion of brain | 12,757 | 2,551 | 3.0% | 0.69 (0.68–0.71) | 7,212 | 1,442 | 4.0% | 0.84 (0.82–0.86) | 5,545 | 1,109 | 2.2% | 0.57 (0.56–0.59) |
| Brain, NOS | 20,918 | 4,184 | 4.8% | 1.17 (1.16–1.19) | 10,648 | 2,130 | 5.9% | 1.29 (1.26–1.31) | 10,270 | 2,054 | 4.1% | 1.07 (1.05–1.09) |
| Spinal cord and cauda equina | 12,889 | 2,578 | 3.0% | 0.76 (0.75–0.78) | 6,835 | 1,367 | 3.8% | 0.83 (0.81–0.85) | 6,054 | 1,211 | 2.4% | 0.70 (0.68–0.72) |
| Spinal cord | 12,572 | 2,514 | 2.9% | 0.74 (0.73–0.76) | 6,685 | 1,337 | 3.7% | 0.81 (0.79–0.83) | 5,887 | 1,177 | 2.3% | 0.68 (0.66–0.70) |
| Cauda equina | 381 | 76 | 0.1% | 0.02 (0.02-0.02) | 186 | 37 | 0.1% | 0.02 (0.02–0.03) | 195 | 39 | 0.1% | 0.02 (0.02–0.03) |
| Cranial nerves | 29,908 | 5,982 | 6.9% | 1.68 (1.66–1.69) | 14,071 | 2,814 | 7.8% | 1.64 (1.61–1.67) | 15,837 | 3,167 | 6.3% | 1.72 (1.69–1.74) |
| Olfactory nerve | 41 | 8 | 0.0% | 0.00 (0.00-0.00) | 19 | 4 | 0.0% | 0.00 (0.00-0.00) | 22 | 4 | 0.0% | 0.00 (0.00-0.00) |
| Optic nerve | 1,750 | 350 | 0.4% | 0.12 (0.11–0.12) | 821 | 164 | 0.5% | 0.11 (0.10–0.12) | 929 | 186 | 0.4% | 0.13 (0.12–0.14) |
| Acoustic nerve | 22,196 | 4,439 | 5.1% | 1.22 (1.20–1.24) | 10,458 | 2,092 | 5.8% | 1.20 (1.18–1.23) | 11,738 | 2,348 | 4.7% | 1.24 (1.22–1.26) |
| Cranial nerve, NOS | 5,921 | 1,184 | 1.4% | 0.33 (0.33–0.34) | 2,773 | 555 | 1.5% | 0.33 (0.31–0.34) | 3,148 | 630 | 1.2% | 0.34 (0.33–0.36) |
| Other nervous system | 2,579 | 516 | 0.6% | 0.15 (0.14–0.15) | 1,327 | 265 | 0.7% | 0.16 (0.15–0.17) | 1,252 | 250 | 0.5% | 0.14 (0.13–0.14) |
| Overlapping lesion of brain and central nervous system | 339 | 68 | 0.1% | 0.02 (0.02-0.02) | 185 | 37 | 0.1% | 0.02 (0.02–0.03) | 154 | 31 | 0.1% | 0.02 (0.01–0.02) |
| Nervous system, NOS | 2,253 | 451 | 0.5% | 0.13 (0.12–0.13) | 1,150 | 230 | 0.6% | 0.14 (0.13–0.15) | 1,103 | 221 | 0.4% | 0.12 (0.11–0.13) |
| Meninges | 169,047 | 33,809 | 39.2% | 9.16 (9.12–9.21) | 45,909 | 9,182 | 25.6% | 5.47 (5.41–5.52) | 123,138 | 24,628 | 48.8% | 12.44 (12.37–12.51) |
| Cerebral meninges | 137,656 | 27,531 | 31.9% | 7.46 (7.42–7.50) | 37,698 | 7,540 | 21.0% | 4.48 (4.44–4.53) | 99,958 | 19,992 | 39.6% | 10.10 (10.04–10.17) |
| Spinal meninges | 7,302 | 1,460 | 1.7% | 0.39 (0.38–0.40) | 1,624 | 325 | 0.9% | 0.19 (0.18–0.20) | 5,678 | 1,136 | 2.3% | 0.57 (0.55–0.58) |
| Meninges, NOS | 24,089 | 4,818 | 5.6% | 1.31 (1.29–1.33) | 6,587 | 1,317 | 3.7% | 0.79 (0.77–0.81) | 17,502 | 3,500 | 6.9% | 1.77 (1.74–1.80) |
| Pituitary and craniopharyngeal duct | 78,112 | 15,622 | 18.1% | 4.61 (4.58–4.65) | 34,978 | 6,996 | 19.5% | 4.16 (4.12–4.21) | 43,134 | 8,627 | 17.1% | 5.16 (5.11–5.21) |
| Pituitary gland | 75,996 | 15,199 | 17.6% | 4.49 (4.45–4.52) | 33,876 | 6,775 | 18.9% | 4.02 (3.98–4.07) | 42,120 | 8,424 | 16.7% | 5.04 (4.99–5.09) |
| Craniopharyngeal duct | 2,116 | 423 | 0.5% | 0.13 (0.12–0.13) | 1,102 | 220 | 0.6% | 0.14 (0.13–0.15) | 1,014 | 203 | 0.4% | 0.12 (0.11–0.13) |
| Pineal gland | 1,690 | 338 | 0.4% | 0.11 (0.10–0.11) | 1,012 | 202 | 0.6% | 0.13 (0.12–0.14) | 678 | 136 | 0.3% | 0.08 (0.08–0.09) |
| Olfactory tumors of the nasal cavityd | 739 | 148 | 0.2% | 0.04 (0.04–0.05) | 423 | 85 | 0.2% | 0.05 (0.05–0.06) | 316 | 63 | 0.1% | 0.03 (0.03–0.04) |
| TOTAL | 431,773 | 86,355 | 100.0% | 24.25 (24.17–24.32) | 179,502 | 35,900 | 100.0% | 21.35 (21.25–21.46) | 252,271 | 50,454 | 100.0% | 26.95 (26.85–27.06) |
aAnnual average cases are calculated by dividing the five-year total by five.
bRates are per 100,000 and are age-adjusted to the 2000 US standard population.
cThe sites referred to in this table are loosely based on the categories and site codes defined in the SEER site/histology validation list.
dICD-O-3 histology codes 9522–9523 only.
-Counts and rates are not presented when fewer than 16 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval