Table 15.
Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals for All Brain and Other Central Nervous System Tumors by Histology, Hispanic Ethnicityc, and Race, CBTRUS Statistical Report: U.S. Cancer Statistics – NPCR and SEER, 2014–2018
| Histology | Non-Hispanic | All Hispanic | White Hispanic | Black Hispanic | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | |
| Diffuse Astrocytic and Oligodendroglial Tumors | 75,728 | 15,146 | 4.69 (4.66–4.73) | 7,396 | 1,479 | 3.43 (3.35–3.51) | 6,803 | 1,361 | 3.47 (3.38–3.56) | 190 | 38 | 1.93 (1.64–2.25) |
| Diffuse astrocytoma | 6,864 | 1,373 | 0.49 (0.48–0.51) | 865 | 173 | 0.34 (0.31–0.36) | 777 | 155 | 0.34 (0.31–0.36) | 23 | 5 | 0.15 (0.09–0.24) |
| Anaplastic astrocytoma | 6,490 | 1,298 | 0.45 (0.43–0.46) | 685 | 137 | 0.28 (0.26–0.30) | 622 | 124 | 0.28 (0.26–0.30) | 23 | 5 | 0.19 (0.12–0.30) |
| Glioblastoma | 56,647 | 11,329 | 3.33 (3.30–3.36) | 5,052 | 1,010 | 2.51 (2.44–2.58) | 4,669 | 934 | 2.54 (2.47–2.62) | 135 | 27 | 1.51 (1.25–1.81) |
| Oligodendroglioma | 3,251 | 650 | 0.25 (0.24–0.26) | 455 | 91 | 0.17 (0.15–0.19) | 420 | 84 | 0.17 (0.16–0.19) | -- | -- | -- |
| Anaplastic oligodendroglioma | 1,604 | 321 | 0.11 (0.11–0.12) | 235 | 47 | 0.09 (0.08–0.11) | 218 | 44 | 0.10 (0.08–0.11) | -- | -- | -- |
| Oligoastrocytic tumors | 872 | 174 | 0.06 (0.06–0.07) | 104 | 21 | 0.04 (0.03–0.05) | 97 | 19 | 0.04 (0.03–0.05) | -- | -- | -- |
| Other Astrocytic Tumors | 5,194 | 1,039 | 0.46 (0.44–0.47) | 1,019 | 204 | 0.30 (0.28–0.32) | 905 | 181 | 0.30 (0.28–0.32) | 28 | 6 | 0.15 (0.10–0.23) |
| Pilocytic astrocytoma | 4,455 | 891 | 0.39 (0.38–0.40) | 848 | 170 | 0.25 (0.23–0.27) | 750 | 150 | 0.25 (0.23–0.27) | -- | -- | -- |
| Unique astrocytoma variants | 739 | 148 | 0.06 (0.06–0.07) | 171 | 34 | 0.06 (0.05–0.06) | 155 | 31 | 0.06 (0.05–0.07) | -- | -- | -- |
| Malignant | 447 | 89 | 0.04 (0.03–0.04) | 97 | 19 | 0.03 (0.03–0.04) | 90 | 18 | 0.03 (0.03–0.04) | -- | -- | -- |
| Non-Malignant | 292 | 58 | 0.03 (0.02–0.03) | 74 | 15 | 0.02 (0.02–0.03) | 65 | 13 | 0.02 (0.02–0.03) | -- | -- | -- |
| Ependymal Tumors | 5,921 | 1,184 | 0.43 (0.42–0.45) | 1,005 | 201 | 0.37 (0.35–0.39) | 904 | 181 | 0.37 (0.34–0.39) | 21 | 4 | 0.15 (0.09–0.24) |
| Malignant | 3,324 | 665 | 0.25 (0.24–0.26) | 643 | 129 | 0.23 (0.21–0.25) | 589 | 118 | 0.23 (0.21–0.25) | -- | -- | -- |
| Non-Malignant | 2,597 | 519 | 0.18 (0.18–0.19) | 362 | 72 | 0.14 (0.12–0.16) | 315 | 63 | 0.13 (0.12–0.15) | -- | -- | -- |
| Other Gliomas | 7,441 | 1,488 | 0.56 (0.55–0.58) | 1,134 | 227 | 0.41 (0.39–0.44) | 1,006 | 201 | 0.41 (0.38–0.44) | 40 | 8 | 0.34 (0.23–0.49) |
| Glioma malignant, NOS | 7,357 | 1,471 | 0.56 (0.54–0.57) | 1,114 | 223 | 0.41 (0.38–0.43) | 989 | 198 | 0.40 (0.38–0.43) | 40 | 8 | 0.34 (0.23–0.49) |
| Other neuroepithelial tumors | 84 | 17 | 0.01 (0.01-0.01) | 20 | 4 | 0.01 (0.00–0.01) | 17 | 3 | 0.01 (0.00–0.01) | -- | -- | -- |
| Neuronal and Mixed Neuronal-Glial Tumors | 4,425 | 885 | 0.35 (0.34–0.36) | 725 | 145 | 0.24 (0.22–0.25) | 644 | 129 | 0.23 (0.22–0.25) | 23 | 5 | 0.12 (0.08–0.19) |
| Malignant | 852 | 170 | 0.06 (0.05–0.06) | 126 | 25 | 0.05 (0.04–0.06) | 113 | 23 | 0.05 (0.04–0.06) | -- | -- | -- |
| Non-Malignant | 3,573 | 715 | 0.29 (0.28–0.30) | 599 | 120 | 0.19 (0.17–0.20) | 531 | 106 | 0.19 (0.17–0.20) | -- | -- | -- |
| Choroid Plexus Tumors | 692 | 138 | 0.06 (0.05–0.06) | 155 | 31 | 0.05 (0.04–0.06) | 143 | 29 | 0.05 (0.04–0.06) | -- | -- | -- |
| Malignant | 106 | 21 | 0.01 (0.01-0.01) | 25 | 5 | 0.01 (0.00–0.01) | 24 | 5 | 0.01 (0.01-0.01) | -- | -- | -- |
| Non-Malignant | 586 | 117 | 0.05 (0.04–0.05) | 130 | 26 | 0.04 (0.04–0.05) | 119 | 24 | 0.04 (0.04–0.05) | -- | -- | -- |
| Tumors of the Pineal Region | 642 | 128 | 0.05 (0.05-0.05) | 101 | 20 | 0.03 (0.03–0.04) | 93 | 19 | 0.04 (0.03–0.04) | -- | -- | -- |
| Malignant | 353 | 71 | 0.03 (0.03-0.03) | 69 | 14 | 0.02 (0.02–0.03) | 64 | 13 | 0.02 (0.02–0.03) | -- | -- | -- |
| Non-Malignant | 289 | 58 | 0.02 (0.02-0.02) | 32 | 6 | 0.01 (0.01–0.02) | 29 | 6 | 0.01 (0.01–0.02) | -- | -- | -- |
| Embryonal Tumors | 2,546 | 509 | 0.23 (0.22–0.24) | 706 | 141 | 0.21 (0.19–0.22) | 638 | 128 | 0.21 (0.19–0.23) | 20 | 4 | 0.09 (0.06–0.15) |
| Tumors of Cranial and Paraspinal Nerves | 33,334 | 6,667 | 2.16 (2.14–2.18) | 3,350 | 670 | 1.42 (1.37–1.48) | 3,014 | 603 | 1.42 (1.36–1.47) | 80 | 16 | 0.71 (0.55–0.90) |
| Nerve sheath tumors | 33,304 | 6,661 | 2.16 (2.13–2.18) | -- | -- | -- | -- | -- | -- | 80 | 16 | 0.71 (0.55–0.90) |
| Malignant | 169 | 34 | 0.01 (0.01-0.01) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 33,135 | 6,627 | 2.15 (2.12–2.17) | -- | -- | -- | -- | -- | -- | 80 | 16 | 0.71 (0.55–0.90) |
| Other tumors of cranial and paraspinal nerves | 30 | 6 | 0.00 (0.00-0.00) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Tumors of Meninges | 157,188 | 31,438 | 9.62 (9.57–9.66) | 17,380 | 3,476 | 8.86 (8.72–8.99) | 15,801 | 3,160 | 8.82 (8.67–8.96) | 475 | 95 | 5.50 (4.98–6.06) |
| Meningiomas | 151,893 | 30,379 | 9.25 (9.20–9.29) | 16,539 | 3,308 | 8.53 (8.39–8.66) | 15,038 | 3,008 | 8.48 (8.34–8.63) | 463 | 93 | 5.41 (4.89–5.96) |
| Malignant | 1,488 | 298 | 0.09 (0.09-0.09) | 211 | 42 | 0.11 (0.09–0.12) | 198 | 40 | 0.11 (0.09–0.13) | -- | -- | -- |
| Non-Malignant | 150,405 | 30,081 | 9.16 (9.11–9.20) | 16,328 | 3,266 | 8.42 (8.28–8.55) | 14,840 | 2,968 | 8.37 (8.23–8.52) | 457 | 91 | 5.33 (4.82–5.88) |
| Mesenchymal tumors | 5,175 | 1,035 | 0.36 (0.35–0.37) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Malignant | 657 | 131 | 0.05 (0.04–0.05) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 4,518 | 904 | 0.32 (0.31–0.33) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Primary melanocytic lesions | 120 | 24 | 0.01 (0.01-0.01) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Malignant | 81 | 16 | 0.01 (0.00–0.01) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 39 | 8 | 0.00 (0.00-0.00) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Lymphomas and Hematopoietic Neoplasms | 7,518 | 1,504 | 0.45 (0.44–0.46) | 1,040 | 208 | 0.52 (0.49–0.56) | 974 | 195 | 0.54 (0.50–0.58) | 19 | 4 | 0.19 (0.11–0.30) |
| Lymphoma | 7,449 | 1,490 | 0.45 (0.44–0.46) | -- | -- | -- | -- | -- | -- | 19 | 4 | 0.19 (0.11–0.30) |
| Other hematopoietic neoplasms | 69 | 14 | 0.00 (0.00–0.01) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Germ Cell Tumors | 960 | 192 | 0.08 (0.08–0.09) | 292 | 58 | 0.09 (0.08–0.10) | 262 | 52 | 0.09 (0.08–0.10) | -- | -- | -- |
| Malignant | 826 | 165 | 0.07 (0.07–0.08) | 259 | 52 | 0.08 (0.07–0.09) | 232 | 46 | 0.08 (0.07–0.09) | -- | -- | -- |
| Non-Malignant | 134 | 27 | 0.01 (0.01-0.01) | 33 | 7 | 0.01 (0.01–0.02) | 30 | 6 | 0.01 (0.01–0.02) | -- | -- | -- |
| Tumors of Sellar Region | 64,407 | 12,881 | 4.47 (4.44–4.51) | 12,677 | 2,535 | 5.10 (5.01–5.20) | 11,317 | 2,263 | 5.05 (4.96–5.15) | 406 | 81 | 3.37 (3.02–3.74) |
| Tumors of the pituitary | 61,761 | 12,352 | 4.28 (4.24–4.31) | 12,184 | 2,437 | 4.93 (4.83–5.02) | 10,873 | 2,175 | 4.87 (4.78–4.97) | 388 | 78 | 3.26 (2.91–3.63) |
| Malignant | 102 | 20 | 0.01 (0.01-0.01) | 23 | 5 | 0.01 (0.01–0.02) | 19 | 4 | 0.01 (0.01–0.02) | -- | -- | -- |
| Non-Malignant | 61,659 | 12,332 | 4.27 (4.24–4.31) | 12,161 | 2,432 | 4.91 (4.82–5.01) | 10,854 | 2,171 | 4.86 (4.77–4.96) | 388 | 78 | 3.26 (2.91–3.63) |
| Craniopharyngioma | 2,646 | 529 | 0.20 (0.19–0.20) | 493 | 99 | 0.18 (0.16–0.20) | 444 | 89 | 0.18 (0.16–0.20) | 18 | 4 | 0.11 (0.06–0.18) |
| Unclassified Tumors | 16,472 | 3,294 | 1.07 (1.05–1.09) | 2,325 | 465 | 1.08 (1.03–1.13) | 2,109 | 422 | 1.08 (1.03–1.13) | 61 | 12 | 0.60 (0.44–0.79) |
| Hemangioma | 3,483 | 697 | 0.25 (0.24–0.26) | 658 | 132 | 0.26 (0.24–0.28) | 604 | 121 | 0.26 (0.24–0.28) | -- | -- | -- |
| Neoplasm, unspecified | 12,533 | 2,507 | 0.79 (0.77–0.80) | 1,560 | 312 | 0.78 (0.74–0.83) | 1,409 | 282 | 0.78 (0.74–0.83) | 38 | 8 | 0.44 (0.29–0.61) |
| Malignant | 6,085 | 1,217 | 0.36 (0.35–0.37) | 607 | 121 | 0.35 (0.32–0.38) | 562 | 112 | 0.35 (0.32–0.38) | -- | -- | -- |
| Non-Malignant | 6,448 | 1,290 | 0.42 (0.41–0.43) | 953 | 191 | 0.44 (0.41–0.47) | 847 | 169 | 0.43 (0.40–0.46) | -- | -- | -- |
| All other | 456 | 91 | 0.03 (0.03–0.04) | 107 | 21 | 0.04 (0.03–0.05) | 96 | 19 | 0.04 (0.03–0.05) | -- | -- | -- |
| Malignant | 67 | 13 | 0.01 (0.00–0.01) | 16 | 3 | 0.00 (0.00–0.01) | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 389 | 78 | 0.03 (0.03-0.03) | 91 | 18 | 0.04 (0.03–0.04) | -- | -- | -- | -- | -- | -- |
| TOTAL d | 382,468 | 76,494 | 24.68 (24.60–24.77) | 49,305 | 9,861 | 22.12 (21.91–22.32) | 44,613 | 8,923 | 22.07 (21.86–22.29) | 1,377 | 275 | 13.24 (12.48–14.04) |
| Malignant | 112,174 | 22,435 | 7.31 (7.26–7.35) | 13,350 | 2,670 | 5.77 (5.66–5.87) | 12,213 | 2,443 | 5.83 (5.72–5.94) | 337 | 67 | 3.02 (2.67–3.40) |
| Non-Malignant | 270,294 | 54,059 | 17.38 (17.31–17.45) | 35,955 | 7,191 | 16.35 (16.17–16.53) | 32,400 | 6,480 | 16.24 (16.06–16.43) | 1,040 | 208 | 10.22 (9.55–10.93) |
aAnnual average cases are calculated by dividing the five-ear total by five.
bRates are per 100,000 and are age-adjusted to the 2000 US standard population.
cHispanic ethnicity is not mutually exclusive of race; Classified using the North American Association of Central Cancer Registries Hispanic Identification Algorithm, version 2 (NHIA v2).
dRefers to all brain tumors including histologies not presented in this table
- Counts and rates are not presented when fewer than 16 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval; NOS, not otherwise specified.