Table 18.
Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals for Children and Adolescents (Age 0–19 Years), Brain and Other Central Nervous System Tumors by Histology, Hispanic Ethnicityc, and Race, CBTRUS Statistical Report: U.S. Cancer Statistics – NPCR and SEER, 2014–2018
| Histology | Non-Hispanic | All Hispanic | White Hispanic | Black Hispanic | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | |
| Diffuse Astrocytic and Oligodendroglial Tumors | 1,843 | 369 | 0.59 (0.57–0.62) | 405 | 81 | 0.40 (0.37–0.45) | 367 | 73 | 0.41 (0.37–0.46) | -- | -- | -- |
| Diffuse astrocytoma | 798 | 160 | 0.26 (0.24–0.28) | 148 | 30 | 0.15 (0.12–0.17) | 131 | 26 | 0.15 (0.12–0.17) | -- | -- | -- |
| Anaplastic astrocytoma | 288 | 58 | 0.09 (0.08–0.10) | 77 | 15 | 0.08 (0.06–0.10) | 69 | 14 | 0.08 (0.06–0.10) | -- | -- | -- |
| Glioblastoma | 555 | 111 | 0.18 (0.16–0.19) | 145 | 29 | 0.15 (0.12–0.17) | 134 | 27 | 0.15 (0.13–0.18) | -- | -- | -- |
| Oligodendroglioma | 144 | 29 | 0.05 (0.04–0.05) | 20 | 4 | 0.02 (0.01–0.03) | 19 | 4 | 0.02 (0.01–0.03) | -- | -- | -- |
| Anaplastic oligodendroglioma | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Oligoastrocytic tumors | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other Astrocytic Tumors | 3,590 | 718 | 1.17 (1.13–1.21) | 781 | 156 | 0.76 (0.71–0.82) | 701 | 140 | 0.78 (0.72–0.84) | 18 | 4 | 0.30 (0.18–0.47) |
| Pilocytic astrocytoma | 3,198 | 640 | 1.04 (1.00–1.08) | 679 | 136 | 0.66 (0.61–0.72) | 611 | 122 | 0.68 (0.62–0.73) | -- | -- | -- |
| Unique astrocytoma variants | 392 | 78 | 0.13 (0.11–0.14) | 102 | 20 | 0.10 (0.08–0.12) | 90 | 18 | 0.10 (0.08–0.12) | -- | -- | -- |
| Malignant | 183 | 37 | 0.06 (0.05–0.07) | 44 | 9 | 0.04 (0.03–0.06) | 40 | 8 | 0.05 (0.03–0.06) | -- | -- | -- |
| Non-Malignant | 209 | 42 | 0.07 (0.06–0.08) | 58 | 12 | 0.06 (0.04–0.07) | 50 | 10 | 0.06 (0.04–0.07) | -- | -- | -- |
| Ependymal Tumors | 908 | 182 | 0.29 (0.28–0.31) | 268 | 54 | 0.26 (0.23–0.30) | 245 | 49 | 0.27 (0.24–0.31) | -- | -- | -- |
| Malignant | 761 | 152 | 0.25 (0.23–0.27) | 224 | 45 | 0.22 (0.19–0.25) | 208 | 42 | 0.23 (0.20–0.26) | -- | -- | -- |
| Non-Malignant | 147 | 29 | 0.05 (0.04–0.06) | 44 | 9 | 0.04 (0.03–0.06) | 37 | 7 | 0.04 (0.03–0.06) | -- | -- | -- |
| Other Gliomas | 2,576 | 515 | 0.84 (0.81–0.87) | 557 | 111 | 0.55 (0.50–0.59) | 495 | 99 | 0.55 (0.50–0.60) | 19 | 4 | 0.30 (0.18–0.47) |
| Glioma malignant, NOS | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other neuroepithelial tumors | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Neuronal and Mixed Neuronal-Glial Tumors | 1,656 | 331 | 0.53 (0.51–0.56) | 356 | 71 | 0.36 (0.32–0.39) | 320 | 64 | 0.36 (0.32–0.40) | -- | -- | -- |
| Malignant | 110 | 22 | 0.04 (0.03–0.04) | 30 | 6 | 0.03 (0.02–0.04) | 27 | 5 | 0.03 (0.02–0.04) | -- | -- | -- |
| Non-Malignant | 1,546 | 309 | 0.50 (0.47–0.52) | 326 | 65 | 0.33 (0.29–0.36) | 293 | 59 | 0.33 (0.29–0.37) | -- | -- | -- |
| Choroid Plexus Tumors | 324 | 65 | 0.11 (0.09–0.12) | 92 | 18 | 0.09 (0.07–0.11) | 85 | 17 | 0.09 (0.07–0.12) | -- | -- | -- |
| Malignant | 83 | 17 | 0.03 (0.02–0.03) | 21 | 4 | 0.02 (0.01–0.03) | 20 | 4 | 0.02 (0.01–0.03) | -- | -- | -- |
| Non-Malignant | 241 | 48 | 0.08 (0.07–0.09) | 71 | 14 | 0.07 (0.05–0.09) | 65 | 13 | 0.07 (0.06–0.09) | -- | -- | -- |
| Tumors of the Pineal Region | 173 | 35 | 0.06 (0.05–0.06) | 40 | 8 | 0.04 (0.03–0.05) | 34 | 7 | 0.04 (0.03–0.05) | -- | -- | -- |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Embryonal Tumors | 1,877 | 375 | 0.62 (0.59–0.64) | 520 | 104 | 0.50 (0.46–0.55) | 472 | 94 | 0.52 (0.47–0.57) | 18 | 4 | 0.28 (0.16–0.44) |
| Medulloblastoma | 1,304 | 261 | 0.43 (0.40–0.45) | 348 | 70 | 0.34 (0.30–0.38) | 318 | 64 | 0.35 (0.31–0.39) | -- | -- | -- |
| Primitive neuroectodermal tumors | 155 | 31 | 0.05 (0.04–0.06) | 53 | 11 | 0.05 (0.04–0.07) | 48 | 10 | 0.05 (0.04–0.07) | -- | -- | -- |
| Atypical teratoid/rhabdoid tumor | 300 | 60 | 0.10 (0.09–0.11) | 82 | 16 | 0.08 (0.06–0.10) | 75 | 15 | 0.08 (0.06–0.10) | -- | -- | -- |
| All other embryonal | 118 | 24 | 0.04 (0.03–0.05) | 37 | 7 | 0.04 (0.02–0.05) | 31 | 6 | 0.03 (0.02–0.05) | -- | -- | -- |
| Tumors of Cranial and Paraspinal Nerves | 960 | 192 | 0.31 (0.29–0.33) | 242 | 48 | 0.24 (0.21–0.27) | 212 | 42 | 0.24 (0.21–0.27) | -- | -- | -- |
| Nerve sheath tumors | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other tumors of cranial and paraspinal nerves | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Tumors of Meninges | 995 | 199 | 0.32 (0.30–0.34) | 296 | 59 | 0.30 (0.27–0.33) | 269 | 54 | 0.31 (0.27–0.34) | -- | -- | -- |
| Meningiomas | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Mesenchymal tumors | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Primary melanocytic lesions | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Lymphomas and Hematopoietic Neoplasms | 113 | 23 | 0.04 (0.03–0.04) | 22 | 4 | 0.02 (0.01–0.03) | 20 | 4 | 0.02 (0.01–0.03) | -- | -- | -- |
| Lymphoma | -- | -- | -- | -- | -- | -- | 20 | 4 | 0.02 (0.01–0.03) | -- | -- | -- |
| Other hematopoietic neoplasms | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Germ Cell Tumors | 636 | 127 | 0.21 (0.19–0.22) | 213 | 43 | 0.21 (0.19–0.24) | 193 | 39 | 0.22 (0.19–0.25) | -- | -- | -- |
| Malignant | 556 | 111 | 0.18 (0.16–0.19) | 196 | 39 | 0.20 (0.17–0.23) | 177 | 35 | 0.20 (0.17–0.23) | -- | -- | -- |
| Non-Malignant | 80 | 16 | 0.03 (0.02–0.03) | 17 | 3 | 0.02 (0.01–0.03) | 16 | 3 | 0.02 (0.01–0.03) | -- | -- | -- |
| Tumors of Sellar Region | 3,256 | 651 | 1.03 (0.99–1.07) | 1,228 | 246 | 1.26 (1.19–1.34) | 1,105 | 221 | 1.28 (1.21–1.36) | 36 | 7 | 0.63 (0.44–0.87) |
| Tumors of the pituitary | 2,604 | 521 | 0.82 (0.79–0.85) | 1,035 | 207 | 1.07 (1.01–1.14) | 927 | 185 | 1.08 (1.01–1.15) | -- | -- | -- |
| Craniopharyngioma | 652 | 130 | 0.21 (0.20–0.23) | 193 | 39 | 0.19 (0.16–0.22) | 178 | 36 | 0.20 (0.17–0.23) | -- | -- | -- |
| Unclassified Tumors | 1,223 | 245 | 0.39 (0.37–0.42) | 347 | 69 | 0.35 (0.31–0.38) | 303 | 61 | 0.34 (0.30–0.38) | -- | -- | -- |
| Hemangioma | 373 | 75 | 0.12 (0.11–0.13) | 113 | 23 | 0.11 (0.09–0.14) | 102 | 20 | 0.12 (0.09–0.14) | -- | -- | -- |
| Neoplasm, unspecified | 687 | 137 | 0.22 (0.21–0.24) | 181 | 36 | 0.18 (0.16–0.21) | 153 | 31 | 0.17 (0.15–0.20) | -- | -- | -- |
| Malignant | 174 | 35 | 0.06 (0.05–0.07) | 45 | 9 | 0.04 (0.03–0.06) | 39 | 8 | 0.04 (0.03–0.06) | -- | -- | -- |
| Non-Malignant | 513 | 103 | 0.17 (0.15–0.18) | 136 | 27 | 0.14 (0.11–0.16) | 114 | 23 | 0.13 (0.11–0.16) | -- | -- | -- |
| All other | 163 | 33 | 0.05 (0.05–0.06) | 53 | 11 | 0.05 (0.04–0.07) | 48 | 10 | 0.05 (0.04–0.07) | -- | -- | -- |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| TOTAL d | 20,130 | 4,026 | 6.50 (6.41–6.59) | 5,367 | 1,073 | 5.35 (5.21–5.49) | 4,821 | 964 | 5.43 (5.28–5.59) | 160 | 32 | 2.63 (2.23–3.07) |
| Malignant | 11,767 | 2,353 | 3.83 (3.76–3.90) | 2,819 | 564 | 2.77 (2.66–2.87) | 2,542 | 508 | 2.83 (2.72–2.94) | 86 | 17 | 1.37 (1.09–1.69) |
| Non-Malignant | 8,363 | 1,673 | 2.67 (2.62–2.73) | 2,548 | 510 | 2.58 (2.48–2.68) | 2,279 | 456 | 2.61 (2.50–2.72) | 74 | 15 | 1.26 (0.99–1.58) |
aAnnual average cases are calculated by dividing the five-year total by five.
bRates are per 100,000 and are age-adjusted to the 2000 US standard population.
cHispanic ethnicity is not mutually exclusive of race; Classified using the North American Association of Central Cancer Registries Hispanic Identification Algorithm, version 2 (NHIA v2).
dRefers to all brain tumors including histologies not presented in this table.
- Counts and rates are not presented when fewer than 16 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval; NOS, not otherwise specified.