Table 4.
Distribution of Brain Molecular Markers for Select Histologically-Confirmed Glioma and Embryonal Tumor Histologies, CBTRUS Statistical Report: U.S. Cancer Statistics – NPCR and SEER, 2018
| Histology | Frequency (%) |
|---|---|
| Diffuse Astrocytoma | |
| 9400/3: Diffuse astrocytoma, IDH-mutant a | 564 (43.2%) |
| 9400/3: Diffuse astrocytoma, IDH-wildtype a | 404 (30.9%) |
| 9400/3: Diffuse astrocytoma, IDH Status Unknown | 338 (25.9%) |
| Anaplastic Astrocytoma | |
| 9401/3: Anaplastic astrocytoma, IDH-mutant a | 581 (42.6%) |
| 9401/3: Anaplastic astrocytoma, IDH-wildtype a | 581 (42.6%) |
| 9401/3: Anaplastic astrocytoma, IDH Status Unknown | 201 (14.7%) |
| Glioblastoma | |
| 9440/3: Glioblastoma, IDH-wildtype a | 8,825 (74.2%) |
| 9440/3: Glioblastoma, IDH Status Unknown | 2,512 (21.1%) |
| 9441/3: Giant cell glioblastoma | 83 (0.7%) |
| 9442/3: Gliosarcoma | 238 (2%) |
| 9445/3: Glioblastoma, IDH-mutant b | 237 (2%) |
| Oligodendroglioma | |
| 9450/3: Oligodendroglioma, IDH-mutant and 1 p/19q co-deleted a | 582 (88.9%) |
| 9450/3: Oligodendroglioma, NOS | 73 (11.1%) |
| Anaplastic Oligodendroglioma | |
| 9451/3: Anaplastic oligodendroglioma, IDH-mutant and 1 p/19q co-deleted a | 295 (91.9%) |
| 9451/3: Oligodendroglioma, anaplastic | 26 (8.1%) |
| Medulloblastoma | |
| 9470/3: Medulloblastoma, NOS | 211 (50.1%) |
| 9471/3: Desmoplastic nodular medulloblastoma | 20 (4.8%) |
| 9471/3: Medulloblastoma, SHH-activated and TP53-wildtypea | 84 (20%) |
| 9474/3: Large cell medulloblastoma | 36 (8.6%) |
| 9475/3: Medulloblastoma, WNT-activated, NOS b | -- |
| 9476/3: Medulloblastoma, SHH-activated and TP53-mutant b | -- |
| 9477/3: Medulloblastoma, non-WNT/non-SHH b | 51 (12.1%) |
aCollected in NAACCR Item #3816, Brain Molecular Markers.
bNew ICD-O-3 codes implemented in 2018.
-- Cases and rates are not presented when fewer than 16 cases were reported for the specific category.