Table 5.
Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals for All Brain and Other Central Nervous System Tumors by Major Histology Grouping, Histology, Behavior, and Sex, CBTRUS Statistical Report: U.S. Cancer Statistics – NPCR and SEER,2014–2018
| Histology | Total | Male | Female | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-Year Total | Annual Average | % of all tumors | Median Age | Rate (95% CI) | 5-Year Total |
Annual Average | % Malignantc | Rate (95% CI) | 5-Year Total | Annual Average | % Malignantc | Rate (95% CI) | |
| Diffuse Astrocytic and Oligodendroglial Tumors | 83,124 | 16,625 | 19.3 | 62 | 4.52 (4.49–4.55) | 47,749 | 9,550 | 100.0 | 5.51 (5.46–5.56) | 35,375 | 7,075 | 100.0 | 3.65 (3.61–3.69) |
| Diffuse astrocytoma | 7,729 | 1,546 | 1.8 | 46 | 0.46 (0.45–0.48) | 4,336 | 867 | 100.0 | 0.54 (0.52–0.55) | 3,393 | 679 | 100.0 | 0.40 (0.39–0.41) |
| Anaplastic astrocytoma | 7,175 | 1,435 | 1.7 | 53 | 0.42 (0.41–0.43) | 3,938 | 788 | 100.0 | 0.48 (0.46–0.49) | 3,237 | 647 | 100.0 | 0.36 (0.35–0.38) |
| Glioblastoma | 61,699 | 12,340 | 14.3 | 65 | 3.23 (3.20–3.26) | 35,874 | 7,175 | 100.0 | 4.04 (4.00–4.09) | 25,825 | 5,165 | 100.0 | 2.53 (2.50–2.56) |
| Oligodendroglioma | 3,706 | 741 | 0.9 | 43 | 0.23 (0.23–0.24) | 2,054 | 411 | 100.0 | 0.26 (0.25–0.27) | 1,652 | 330 | 100.0 | 0.21 (0.20–0.22) |
| Anaplastic oligodendroglioma | 1,839 | 368 | 0.4 | 49 | 0.11 (0.11–0.12) | 1,014 | 203 | 99.8 | 0.12 (0.12–0.13) | 825 | 165 | 100.0 | 0.10 (0.09–0.10) |
| Oligoastrocytic tumors | 976 | 195 | 0.2 | 43 | 0.06 (0.06-0.06) | 533 | 107 | 100.0 | 0.07 (0.06–0.07) | 443 | 89 | 99.8 | 0.05 (0.05–0.06) |
| Other Astrocytic Tumors | 6,213 | 1,243 | 1.4 | 12 | 0.42 (0.41–0.43) | 3,218 | 644 | 93.5 | 0.43 (0.41–0.44) | 2,995 | 599 | 94.8 | 0.41 (0.40–0.43) |
| Pilocytic astrocytoma | 5,303 | 1,061 | 1.2 | 11 | 0.36 (0.35–0.37) | 2,728 | 546 | 100.0 | 0.36 (0.35–0.38) | 2,575 | 515 | 100.0 | 0.36 (0.34–0.37) |
| Unique astrocytoma variants | 910 | 182 | 0.2 | 17 | 0.06 (0.06-0.06) | 490 | 98 | 57.3 | 0.06 (0.06–0.07) | 420 | 84 | 62.6 | 0.06 (0.05–0.06) |
| Malignant | 544 | 109 | 0.1 | -- | 0.04 (0.03–0.04) | 281 | 56 | -- | 0.04 (0.03–0.04) | 263 | 53 | -- | 0.03 (0.03–0.04) |
| Non-Malignant | 366 | 73 | 0.1 | -- | 0.02 (0.02–0.03) | 209 | 42 | -- | 0.03 (0.02–0.03) | 157 | 31 | -- | 0.02 (0.02–0.03) |
| Ependymal Tumors | 6,926 | 1,385 | 1.6 | 45 | 0.42 (0.41–0.43) | 3,989 | 798 | 54.8 | 0.49 (0.48–0.51) | 2,937 | 587 | 60.6 | 0.36 (0.34–0.37) |
| Malignant | 3,967 | 793 | 0.9 | -- | 0.24 (0.24–0.25) | 2,187 | 437 | -- | 0.27 (0.26–0.28) | 1,780 | 356 | -- | 0.22 (0.21–0.23) |
| Non-Malignant | 2,959 | 592 | 0.7 | -- | 0.18 (0.17–0.18) | 1,802 | 360 | -- | 0.22 (0.21–0.23) | 1,157 | 231 | -- | 0.14 (0.13–0.14) |
| Other Gliomas | 8,575 | 1,715 | 2.0 | 36 | 0.53 (0.52–0.54) | 4,326 | 865 | 99.6 | 0.55 (0.54–0.57) | 4,249 | 850 | 99.6 | 0.51 (0.50–0.53) |
| Glioma malignant, NOS | 8,471 | 1,694 | 2.0 | 36 | 0.53 (0.51–0.54) | 4,289 | 858 | 100.0 | 0.55 (0.53–0.57) | 4,182 | 836 | 100.0 | 0.51 (0.49–0.52) |
| Other neuroepithelial tumors | 104 | 21 | <0.1 | 30 | 0.01 (0.01-0.01) | 37 | 7 | 56.8 | 0.00 (0.00–0.01) | 67 | 13 | 73.1 | 0.01 (0.01-0.01) |
| Neuronal and Mixed Neuronal-Glial Tumors | 5,150 | 1,030 | 1.2 | 26 | 0.33 (0.32–0.34) | 2,753 | 551 | 19.8 | 0.35 (0.34–0.37) | 2,397 | 479 | 18.1 | 0.31 (0.30–0.32) |
| Malignant | 978 | 196 | 0.2 | -- | 0.06 (0.05–0.06) | 545 | 109 | -- | 0.07 (0.06–0.07) | 433 | 87 | -- | 0.05 (0.04–0.05) |
| Non-Malignant | 4,172 | 834 | 1.0 | -- | 0.27 (0.26–0.28) | 2,208 | 442 | -- | 0.29 (0.27–0.30) | 1,964 | 393 | -- | 0.26 (0.25–0.27) |
| Choroid Plexus Tumors | 847 | 169 | 0.2 | 20 | 0.05 (0.05–0.06) | 429 | 86 | 17.2 | 0.06 (0.05–0.06) | 418 | 84 | 13.6 | 0.05 (0.05–0.06) |
| Malignant | 131 | 26 | 0.0 | -- | 0.01 (0.01-0.01) | 74 | 15 | -- | 0.01 (0.01-0.01) | 57 | 11 | -- | 0.01 (0.01-0.01) |
| Non-Malignant | 716 | 143 | 0.2 | -- | 0.05 (0.04–0.05) | 355 | 71 | -- | 0.05 (0.04–0.05) | 361 | 72 | -- | 0.05 (0.04–0.05) |
| Tumors of the Pineal Region | 743 | 149 | 0.2 | 32 | 0.05 (0.04–0.05) | 319 | 64 | 67.1 | 0.04 (0.04-0.04) | 424 | 85 | 49.1 | 0.05 (0.05–0.06) |
| Malignant | 422 | 84 | 0.1 | -- | 0.03 (0.02–0.03) | 214 | 43 | -- | 0.03 (0.02–0.03) | 208 | 42 | -- | 0.03 (0.02–0.03) |
| Non-Malignant | 321 | 64 | 0.1 | -- | 0.02 (0.02-0.02) | 105 | 21 | -- | 0.01 (0.01–0.02) | 216 | 43 | -- | 0.03 (0.02–0.03) |
| Embryonal Tumors | 3,252 | 650 | 0.8 | 8 | 0.22 (0.21–0.23) | 1,947 | 389 | 100.0 | 0.26 (0.25–0.27) | 1,305 | 261 | 99.8 | 0.18 (0.17–0.19) |
| Tumors of Cranial and Paraspinal Nerves | 36,684 | 7,337 | 8.5 | 57 | 2.05 (2.03–2.07) | 17,651 | 3,530 | 0.6 | 2.06 (2.03–2.09) | 19,033 | 3,807 | 0.5 | 2.05 (2.02–2.08) |
| Nerve sheath tumors | 36,647 | 7,329 | 8.5 | 57 | 2.05 (2.03–2.07) | 17,629 | 3,526 | 0.6 | 2.06 (2.03–2.09) | 19,018 | 3,804 | 0.5 | 2.05 (2.02–2.08) |
| Malignant | 208 | 42 | <0.1 | -- | 0.01 (0.01-0.01) | 107 | 21 | -- | 0.01 (0.01–0.02) | 101 | 20 | -- | 0.01 (0.01-0.01) |
| Non-Malignant | 36,439 | 7,288 | 8.4 | -- | 2.04 (2.02–2.06) | 17,522 | 3,504 | -- | 2.04 (2.01–2.08) | 18,917 | 3,783 | -- | 2.04 (2.01–2.07) |
| Other tumors of cranial and paraspinal nerves | 37 | 7 | <0.1 | 55 | 0.00 (0.00-0.00) | -- | -- | -- | -- | -- | -- | -- | -- |
| Tumors of Meninges | 174,568 | 34,914 | 40.4 | 66 | 9.49 (9.44–9.53) | 48,596 | 9,719 | 2.5 | 5.79 (5.74–5.84) | 125,972 | 25,194 | 1.1 | 12.76 (12.69–12.84) |
| Meningiomas | 168,432 | 33,686 | 39.0 | 66 | 9.12 (9.08–9.17) | 45,494 | 9,099 | 1.7 | 5.41 (5.36–5.46) | 122,938 | 24,588 | 0.8 | 12.41 (12.34–12.49) |
| Malignant | 1,699 | 340 | 0.4 | -- | 0.09 (0.09–0.10) | 754 | 151 | -- | 0.09 (0.08–0.09) | 945 | 189 | -- | 0.10 (0.09–0.10) |
| Non-Malignant | 166,733 | 33,347 | 38.6 | -- | 9.03 (8.99–9.08) | 44,740 | 8,948 | -- | 5.33 (5.27–5.38) | 121,993 | 24,399 | -- | 12.32 (12.25–12.39) |
| Mesenchymal tumors | 6,003 | 1,201 | 1.4 | 51 | 0.35 (0.34–0.36) | 3,029 | 606 | 13.4 | 0.37 (0.35–0.38) | 2,974 | 595 | 12.2 | 0.34 (0.33–0.36) |
| Malignant | 769 | 154 | 0.2 | -- | 0.05 (0.04–0.05) | 405 | 81 | 100.0 | 0.05 (0.04–0.05) | 364 | 73 | -- | 0.04 (0.04–0.05) |
| Non-Malignant | 5,234 | 1,047 | 1.2 | -- | 0.31 (0.30–0.32) | 2,624 | 525 | <0.1 | 0.32 (0.31–0.33) | 2,610 | 522 | -- | 0.30 (0.29–0.31) |
| Primary melanocytic lesions | 133 | 27 | <0.1 | 60 | 0.01 (0.01-0.01) | 73 | 15 | 76.7 | 0.01 (0.01-0.01) | 60 | 12 | 55.0 | 0.01 (0.00–0.01) |
| Lymphomas and Hematopoietic Neoplasms | 8,558 | 1,712 | 2.0 | 67 | 0.46 (0.45–0.47) | 4,359 | 872 | 99.9 | 0.50 (0.49–0.52) | 4,199 | 840 | 99.7 | 0.42 (0.40–0.43) |
| Lymphoma | 8,478 | 1,696 | 2.0 | 67 | 0.45 (0.44–0.46) | 4,317 | 863 | 99.9 | 0.50 (0.48–0.52) | 4,161 | 832 | 99.8 | 0.41 (0.40–0.43) |
| Other hematopoietic neoplasms | 80 | 16 | <0.1 | 61 | 0.00 (0.00–0.01) | 42 | 8 | 97.6 | 0.00 (0.00–0.01) | 38 | 8 | 94.7 | 0.00 (0.00–0.01) |
| Germ Cell Tumors | 1,252 | 250 | 0.3 | 15 | 0.08 (0.08–0.09) | 936 | 187 | 89.1 | 0.12 (0.11–0.13) | 316 | 63 | 79.4 | 0.04 (0.04–0.05) |
| Malignant | 1,085 | 217 | 0.3 | -- | 0.07 (0.07–0.08) | 834 | 167 | -- | 0.11 (0.10–0.12) | 251 | 50 | -- | 0.04 (0.03–0.04) |
| Non-Malignant | 167 | 33 | <0.1 | -- | 0.01 (0.01-0.01) | 102 | 20 | -- | 0.01 (0.01–0.02) | 65 | 13 | -- | 0.01 (0.01-0.01) |
| Tumors of Sellar Region | 77,084 | 15,417 | 17.9 | 51 | 4.55 (4.52–4.59) | 34,600 | 6,920 | 0.3 | 4.11 (4.07–4.16) | 42,484 | 8,497 | 0.1 | 5.08 (5.03–5.13) |
| Tumors of the pituitary | 73,945 | 14,789 | 17.1 | 51 | 4.36 (4.33–4.40) | 32,991 | 6,598 | 0.2 | 3.92 (3.87–3.96) | 40,954 | 8,191 | 0.1 | 4.90 (4.85–4.95) |
| Malignant | 125 | 25 | <0.1 | -- | 0.01 (0.01-0.01) | 80 | 16 | -- | 0.01 (0.01-0.01) | 45 | 9 | -- | 0.00 (0.00–0.01) |
| Non-Malignant | 73,820 | 14,764 | 17.1 | -- | 4.36 (4.32–4.39) | 32,911 | 6,582 | -- | 3.91 (3.86–3.95) | 40,909 | 8,182 | -- | 4.89 (4.84–4.94) |
| Craniopharyngioma | 3,139 | 628 | 0.7 | 44 | 0.19 (0.18–0.20) | 1,609 | 322 | 0.6 | 0.20 (0.19–0.21) | 1,530 | 306 | 0.2 | 0.18 (0.17–0.19) |
| Unclassified Tumors | 18,797 | 3,759 | 4.4 | 65 | 1.07 (1.05–1.08) | 8,630 | 1,726 | 37.7 | 1.07 (1.05–1.10) | 10,167 | 2,033 | 34.7 | 1.07 (1.05–1.09) |
| Hemangioma | 4,141 | 828 | 1.0 | 49 | 0.25 (0.24–0.26) | 1,909 | 382 | 0.1 | 0.24 (0.23–0.25) | 2,232 | 446 | 0.1 | 0.26 (0.25–0.27) |
| Neoplasm, unspecified | 14,093 | 2,819 | 3.3 | 70 | 0.78 (0.77–0.80) | 6,420 | 1,284 | 50.0 | 0.80 (0.78–0.82) | 7,673 | 1,535 | 45.4 | 0.78 (0.76–0.79) |
| Malignant | 6,692 | 1,338 | 1.5 | -- | 0.36 (0.35–0.37) | 3,209 | 642 | -- | 0.40 (0.39–0.41) | 3,483 | 697 | -- | 0.33 (0.32–0.34) |
| Non-Malignant | 7,401 | 1,480 | 1.7 | -- | 0.42 (0.41–0.43) | 3,211 | 642 | -- | 0.40 (0.39–0.41) | 4,190 | 838 | -- | 0.45 (0.43–0.46) |
| All other | 563 | 113 | 0.1 | 34 | 0.04 (0.03–0.04) | 301 | 60 | 13.0 | 0.04 (0.03–0.04) | 262 | 52 | 16.8 | 0.03 (0.03–0.04) |
| Malignant | 83 | 17 | <0.1 | -- | 0.01 (0.00–0.01) | 39 | 8 | -- | 0.01 (0.00–0.01) | 44 | 9 | -- | 0.01 (0.00–0.01) |
| Non-Malignant | 480 | 96 | 0.1 | -- | 0.03 (0.03-0.03) | 262 | 52 | -- | 0.03 (0.03–0.04) | 218 | 44 | -- | 0.03 (0.02–0.03) |
| TOTAL e | 431,773 | 86,355 | 100.0 | 61 | 24.25 (24.17–24.32) | 179,502 | 35,900 | 38.9 | 21.35 (21.25–21.46) | 252,271 | 50,454 | 22.1 | 26.95 (26.85–27.06) |
| Malignant | 125,524 | 25,105 | 29.1 | -- | 7.06 (7.02–7.10) | 69,866 | 13,973 | -- | 8.28 (8.22–8.34) | 55,658 | 11,132 | -- | 5.98 (5.93–6.03) |
| Non-Malignant | 306,249 | 61,250 | 70.9 | -- | 17.19 (17.12–17.25) | 109,636 | 21,927 | -- | 13.07 (12.99–13.15) | 196,613 | 39,323 | -- | 20.97 (20.88–21.07) |
aAnnual average cases are calculated by dividing the five-year total by five.
bRates are per 100,000 and are age-adjusted to the 2000 US standard population.
cAssigned behavior code of /3 (see Table 2).
dAssigned behavior code of /0 or /1 (see Table 2).
eRefers to all brain tumors including histologies not presented in this table.
-- Counts and rates are not presented when fewer than 16 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval; NOS, not otherwise specified