Table 9.
Five-Year Total, Average Annual Age-Adjusted and Age-Specific Incidence Ratesa with 95% Confidence Intervals for Adults (Age 20+ Years), Brain and Other Central Nervous System Tumors by Histology, and Age Group at Diagnosis, CBTRUS Statistical Report: U.S. Cancer Statistics – NPCR and SEER, 2014–2018
| Histology | 20–34 Years | 35–44 Years | 45–54 Years | 55–64 Years | 65–74 Years | 75–84 Years | 85+ Years | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | |
| Diffuse Astrocytic and Oligodendroglial Tumors | 6,130 | 1,226 | 1.86 (1.81–1.91) | 6,190 | 1,238 | 3.05 (2.98–3.13) | 11,336 | 2,267 | 5.22 (5.12–5.32) | 20,324 | 4,065 | 9.79 (9.65–9.92) | 21,474 | 4,295 | 15.25 (15.05–15.46) | 12,289 | 2,458 | 17.17 (16.87–17.48) | 3,133 | 627 | 9.87 (9.53–10.22) |
| Diffuse astrocytoma | 1,699 | 340 | 0.51 (0.49–0.54) | 1,064 | 213 | 0.52 (0.49–0.56) | 1,013 | 203 | 0.48 (0.45–0.51) | 1,171 | 234 | 0.57 (0.54–0.60) | 1,078 | 216 | 0.76 (0.72–0.81) | 606 | 121 | 0.85 (0.78–0.92) | 152 | 30 | 0.48 (0.41–0.56) |
| Anaplastic astrocytoma | 1,330 | 266 | 0.40 (0.38–0.42) | 1,029 | 206 | 0.51 (0.48–0.54) | 1,074 | 215 | 0.50 (0.47–0.53) | 1,402 | 280 | 0.68 (0.64–0.71) | 1,234 | 247 | 0.88 (0.83–0.93) | 618 | 124 | 0.87 (0.80–0.94) | 123 | 25 | 0.39 (0.32–0.46) |
| Glioblastoma | 1,624 | 325 | 0.49 (0.47–0.52) | 2,626 | 525 | 1.30 (1.25–1.35) | 7,822 | 1,564 | 3.57 (3.49–3.65) | 16,643 | 3,329 | 8.00 (7.88–8.12) | 18,582 | 3,716 | 13.21 (13.02–13.40) | 10,870 | 2,174 | 15.18 (14.90–15.47) | 2,832 | 566 | 8.92 (8.60–9.26) |
| Oligodendroglioma | 916 | 183 | 0.28 (0.26–0.30) | 883 | 177 | 0.43 (0.41–0.46) | 820 | 164 | 0.39 (0.36–0.42) | 553 | 111 | 0.27 (0.25–0.29) | 257 | 51 | 0.17 (0.15–0.20) | 94 | 19 | 0.13 (0.11–0.16) | 19 | 4 | 0.06 (0.04–0.09) |
| Anaplastic oligodendroglioma | 308 | 62 | 0.09 (0.08–0.11) | 371 | 74 | 0.18 (0.17–0.20) | 443 | 89 | 0.21 (0.19–0.23) | 401 | 80 | 0.19 (0.18–0.21) | 215 | 43 | 0.15 (0.13–0.17) | -- | -- | -- | -- | -- | -- |
| Oligoastrocytic tumors | 253 | 51 | 0.08 (0.07–0.09) | 217 | 43 | 0.11 (0.09–0.12) | 164 | 33 | 0.08 (0.07–0.09) | 154 | 31 | 0.08 (0.06–0.09) | 108 | 22 | 0.08 (0.06–0.09) | -- | -- | -- | -- | -- | -- |
| Other Astrocytic Tumors | 904 | 181 | 0.27 (0.25–0.29) | 339 | 68 | 0.17 (0.15–0.19) | 241 | 48 | 0.11 (0.10–0.13) | 182 | 36 | 0.09 (0.08–0.10) | 117 | 23 | 0.08 (0.07–0.10) | -- | -- | -- | -- | -- | -- |
| Pilocytic astrocytoma | 693 | 139 | 0.21 (0.19–0.22) | 267 | 53 | 0.13 (0.12–0.15) | 188 | 38 | 0.09 (0.08–0.10) | 144 | 29 | 0.07 (0.06–0.08) | 94 | 19 | 0.07 (0.05–0.08) | -- | -- | -- | -- | -- | -- |
| Unique astrocytoma variants | 211 | 42 | 0.06 (0.05–0.07) | 72 | 14 | 0.04 (0.03–0.04) | 53 | 11 | 0.02 (0.02–0.03) | 38 | 8 | 0.02 (0.01–0.03) | 23 | 5 | 0.02 (0.01–0.02) | -- | -- | -- | -- | -- | -- |
| Malignant | 156 | 31 | 0.05 (0.04–0.05) | 55 | 11 | 0.03 (0.02–0.04) | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 55 | 11 | 0.02 (0.01–0.02) | 17 | 3 | 0.01 (0.00–0.01) | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Ependymal Tumors | 1,157 | 231 | 0.35 (0.33–0.37) | 1,045 | 209 | 0.52 (0.49–0.55) | 1,178 | 236 | 0.55 (0.52–0.59) | 1,171 | 234 | 0.57 (0.54–0.60) | 862 | 172 | 0.60 (0.56–0.64) | 304 | 61 | 0.42 (0.38–0.48) | 33 | 7 | 0.10 (0.07–0.15) |
| Malignant | 605 | 121 | 0.18 (0.17–0.20) | 532 | 106 | 0.26 (0.24–0.29) | 607 | 121 | 0.29 (0.26–0.31) | 611 | 122 | 0.30 (0.27–0.32) | 447 | 89 | 0.32 (0.29–0.35) | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 552 | 110 | 0.17 (0.15–0.18) | 513 | 103 | 0.25 (0.23–0.28) | 571 | 114 | 0.27 (0.25–0.29) | 560 | 112 | 0.27 (0.25–0.30) | 415 | 83 | 0.29 (0.26–0.32) | -- | -- | -- | -- | -- | -- |
| Other Gliomas | 1,041 | 208 | 0.31 (0.30–0.33) | 618 | 124 | 0.30 (0.28–0.33) | 724 | 145 | 0.34 (0.31–0.37) | 860 | 172 | 0.42 (0.39–0.45) | 879 | 176 | 0.63 (0.59–0.67) | 796 | 159 | 1.11 (1.03–1.19) | 524 | 105 | 1.65 (1.51–1.80) |
| Glioma malignant, NOS | 1,020 | 204 | 0.31 (0.29–0.33) | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other neuroepithelial tumors | 21 | 4 | 0.01 (0.00–0.01) | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Neuronal and Mixed Neuronal-Glial Tumors | 1,128 | 226 | 0.34 (0.32–0.36) | 569 | 114 | 0.28 (0.26–0.30) | 513 | 103 | 0.24 (0.22–0.26) | 474 | 95 | 0.23 (0.21–0.25) | 299 | 60 | 0.21 (0.18–0.23) | 127 | 25 | 0.18 (0.15–0.21) | 28 | 6 | 0.09 (0.06–0.13) |
| Malignant | 101 | 20 | 0.03 (0.02–0.04) | 131 | 26 | 0.06 (0.05–0.08) | 172 | 34 | 0.08 (0.07–0.09) | 193 | 39 | 0.09 (0.08–0.11) | 153 | 31 | 0.11 (0.09–0.13) | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 1,027 | 205 | 0.31 (0.29–0.33) | 438 | 88 | 0.21 (0.19–0.24) | 341 | 68 | 0.16 (0.15–0.18) | 281 | 56 | 0.14 (0.12–0.15) | 146 | 29 | 0.10 (0.09–0.12) | -- | -- | -- | -- | -- | -- |
| Choroid Plexus Tumors | 121 | 24 | 0.04 (0.03–0.04) | 79 | 16 | 0.04 (0.03–0.05) | 62 | 12 | 0.03 (0.02–0.04) | 86 | 17 | 0.04 (0.03–0.05) | 48 | 10 | 0.03 (0.02–0.04) | 30 | 6 | 0.04 (0.03–0.06) | -- | -- | -- |
| Tumors of the Pineal Region | 177 | 35 | 0.05 (0.05–0.06) | 98 | 20 | 0.05 (0.04–0.06) | 97 | 19 | 0.05 (0.04–0.06) | 83 | 17 | 0.04 (0.03–0.05) | 62 | 12 | 0.04 (0.03–0.06) | -- | -- | -- | -- | -- | -- |
| Malignant | 101 | 20 | 0.03 (0.02–0.04) | 33 | 7 | 0.02 (0.01–0.02) | 49 | 10 | 0.02 (0.02–0.03) | 32 | 6 | 0.02 (0.01–0.02) | 28 | 6 | 0.02 (0.01–0.03) | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 76 | 15 | 0.02 (0.02–0.03) | 65 | 13 | 0.03 (0.02–0.04) | 48 | 10 | 0.02 (0.02–0.03) | 51 | 10 | 0.02 (0.02–0.03) | 34 | 7 | 0.02 (0.02–0.03) | -- | -- | -- | -- | -- | -- |
| Embryonal Tumors | 468 | 94 | 0.14 (0.13–0.15) | 148 | 30 | 0.07 (0.06–0.08) | 96 | 19 | 0.05 (0.04–0.06) | 78 | 16 | 0.04 (0.03–0.05) | 35 | 7 | 0.03 (0.02–0.04) | -- | -- | -- | -- | -- | -- |
| Tumors of Cranial and Paraspinal Nerves | 3,109 | 622 | 0.94 (0.91–0.98) | 4,403 | 881 | 2.18 (2.12–2.25) | 7,049 | 1,410 | 3.27 (3.19–3.35) | 9,424 | 1,885 | 4.56 (4.47–4.65) | 7,815 | 1,563 | 5.49 (5.37–5.62) | 3,085 | 617 | 4.31 (4.16–4.47) | 597 | 119 | 1.88 (1.73–2.04) |
| Nerve sheath tumors | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other tumors of cranial and paraspinal nerves | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Tumors of Meninges | 5,839 | 1,168 | 1.79 (1.75–1.84) | 12,257 | 2,451 | 6.08 (5.98–6.19) | 24,525 | 4,905 | 11.37 (11.23–11.51) | 36,592 | 7,318 | 17.65 (17.46–17.83) | 43,056 | 8,611 | 30.81 (30.52–31.11) | 32,713 | 6,543 | 45.57 (45.08–46.07) | 18,295 | 3,659 | 57.63 (56.80–58.47) |
| Meningiomas | 4,833 | 967 | 1.49 (1.45–1.53) | 11,428 | 2,286 | 5.68 (5.57–5.78) | 23,500 | 4,700 | 10.89 (10.75–11.03) | 35,428 | 7,086 | 17.08 (16.90–17.26) | 42,135 | 8,427 | 30.17 (29.88–30.46) | 32,254 | 6,451 | 44.93 (44.44–45.42) | 18,187 | 3,637 | 57.29 (56.46–58.13) |
| Malignant | 62 | 12 | 0.02 (0.01–0.02) | 103 | 21 | 0.05 (0.04–0.06) | 217 | 43 | 0.10 (0.09–0.11) | 400 | 80 | 0.19 (0.18–0.21) | 440 | 88 | 0.32 (0.29–0.35) | 316 | 63 | 0.44 (0.39–0.49) | 134 | 27 | 0.42 (0.35–0.50) |
| Non-Malignant | 4,771 | 954 | 1.47 (1.43–1.51) | 11,325 | 2,265 | 5.62 (5.52–5.73) | 23,283 | 4,657 | 10.79 (10.65–10.93) | 35,028 | 7,006 | 16.89 (16.71–17.07) | 41,695 | 8,339 | 29.85 (29.56–30.14) | 31,938 | 6,388 | 44.49 (44.00–44.98) | 18,053 | 3,611 | 56.87 (56.04–57.71) |
| Mesenchymal tumors | -- | -- | -- | -- | -- | -- | 1,006 | 201 | 0.47 (0.44–0.50) | 1,132 | 226 | 0.55 (0.52–0.58) | 898 | 180 | 0.63 (0.59–0.67) | 439 | 88 | 0.61 (0.56–0.67) | -- | -- | -- |
| Malignant | -- | -- | -- | -- | -- | -- | 136 | 27 | 0.06 (0.05–0.08) | 158 | 32 | 0.08 (0.07–0.09) | 102 | 20 | 0.07 (0.06–0.09) | 62 | 12 | 0.09 (0.07–0.11) | -- | -- | -- |
| Non-Malignant | -- | -- | -- | -- | -- | -- | 870 | 174 | 0.41 (0.38–0.43) | 974 | 195 | 0.47 (0.44–0.50) | 796 | 159 | 0.56 (0.52–0.60) | 377 | 75 | 0.53 (0.48–0.58) | -- | -- | -- |
| Primary melanocytic lesions | -- | -- | -- | -- | -- | -- | 19 | 4 | 0.01 (0.00–0.01) | 32 | 6 | 0.02 (0.01–0.02) | 23 | 5 | 0.02 (0.01–0.02) | 20 | 4 | 0.03 (0.02–0.04) | -- | -- | -- |
| Lymphomas and Hematopoietic Neoplasms | 320 | 64 | 0.10 (0.09–0.11) | 427 | 85 | 0.21 (0.19–0.23) | 941 | 188 | 0.43 (0.40–0.46) | 1,919 | 384 | 0.92 (0.88–0.96) | 2,646 | 529 | 1.90 (1.83–1.97) | 1,779 | 356 | 2.49 (2.37–2.61) | 391 | 78 | 1.23 (1.11–1.36) |
| Lymphoma | -- | -- | -- | -- | -- | -- | -- | -- | -- | 1,900 | 380 | 0.91 (0.87–0.95) | 2,624 | 525 | 1.88 (1.81–1.96) | -- | -- | -- | -- | -- | -- |
| Other hematopoietic neoplasms | -- | -- | -- | -- | -- | -- | -- | -- | -- | 19 | 4 | 0.01 (0.01-0.01) | 22 | 4 | 0.02 (0.01–0.02) | -- | -- | -- | -- | -- | -- |
| Germ Cell Tumors | 320 | 64 | 0.10 (0.09–0.11) | 28 | 6 | 0.01 (0.01–0.02) | 23 | 5 | 0.01 (0.01–0.02) | 17 | 3 | 0.01 (0.00–0.01) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Malignant | 296 | 59 | 0.09 (0.08–0.10) | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 24 | 5 | 0.01 (0.00–0.01) | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Tumors of Sellar Region | 14,137 | 2,827 | 4.26 (4.19–4.33) | 11,939 | 2,388 | 5.89 (5.78–5.99) | 12,607 | 2,521 | 5.93 (5.83–6.04) | 13,761 | 2,752 | 6.66 (6.55–6.77) | 12,195 | 2,439 | 8.61 (8.46–8.77) | 6,279 | 1,256 | 8.77 (8.56–8.99) | 1,682 | 336 | 5.30 (5.05–5.56) |
| Tumors of the pituitary | 13,757 | 2,751 | 4.15 (4.08–4.22) | 11,588 | 2,318 | 5.71 (5.61–5.82) | 12,144 | 2,429 | 5.72 (5.61–5.82) | 13,209 | 2,642 | 6.39 (6.28–6.50) | 11,816 | 2,363 | 8.35 (8.20–8.50) | 6,134 | 1,227 | 8.57 (8.36–8.79) | 1,658 | 332 | 5.22 (4.97–5.48) |
| Malignant | -- | -- | -- | 16 | 3 | 0.01 (0.00–0.01) | 28 | 6 | 0.01 (0.01–0.02) | 31 | 6 | 0.02 (0.01–0.02) | 22 | 4 | 0.02 (0.01–0.02) | 16 | 3 | 0.02 (0.01–0.04) | -- | -- | -- |
| Non-Malignant | -- | -- | -- | 11,572 | 2,314 | 5.70 (5.60–5.81) | 12,116 | 2,423 | 5.70 (5.60–5.81) | 13,178 | 2,636 | 6.38 (6.27–6.49) | 11,794 | 2,359 | 8.33 (8.18–8.49) | 6,118 | 1,224 | 8.55 (8.33–8.77) | -- | -- | -- |
| Craniopharyngioma | 380 | 76 | 0.11 (0.10–0.13) | 351 | 70 | 0.17 (0.16–0.19) | 463 | 93 | 0.22 (0.20–0.24) | 552 | 110 | 0.27 (0.24–0.29) | 379 | 76 | 0.27 (0.24–0.29) | 145 | 29 | 0.20 (0.17–0.24) | 24 | 5 | 0.08 (0.05–0.11) |
| Unclassified Tumors | 1,677 | 335 | 0.51 (0.48–0.53) | 1,440 | 288 | 0.71 (0.68–0.75) | 1,976 | 395 | 0.92 (0.88–0.96) | 2,624 | 525 | 1.27 (1.22–1.32) | 2,987 | 597 | 2.14 (2.06–2.22) | 3,281 | 656 | 4.56 (4.40–4.71) | 3,242 | 648 | 10.21 (9.86–10.57) |
| Hemangioma | 705 | 141 | 0.21 (0.20–0.23) | 583 | 117 | 0.29 (0.27–0.31) | 667 | 133 | 0.31 (0.29–0.34) | 727 | 145 | 0.35 (0.33–0.38) | 532 | 106 | 0.37 (0.34–0.41) | 328 | 66 | 0.46 (0.41–0.51) | 113 | 23 | 0.36 (0.29–0.43) |
| Neoplasm, unspecified | 903 | 181 | 0.27 (0.25–0.29) | 810 | 162 | 0.40 (0.37–0.43) | 1,268 | 254 | 0.59 (0.56–0.63) | 1,853 | 371 | 0.90 (0.85–0.94) | 2,396 | 479 | 1.73 (1.66–1.80) | 2,903 | 581 | 4.03 (3.88–4.18) | 3,092 | 618 | 9.74 (9.40–10.09) |
| Malignant | 196 | 39 | 0.06 (0.05–0.07) | 209 | 42 | 0.10 (0.09–0.12) | 434 | 87 | 0.20 (0.18–0.22) | 839 | 168 | 0.40 (0.38–0.43) | 1,222 | 244 | 0.88 (0.83–0.94) | 1,685 | 337 | 2.33 (2.22–2.45) | 1,888 | 378 | 5.95 (5.68–6.22) |
| Non-Malignant | 707 | 141 | 0.21 (0.20–0.23) | 601 | 120 | 0.30 (0.27–0.32) | 834 | 167 | 0.39 (0.37–0.42) | 1,014 | 203 | 0.49 (0.46–0.52) | 1,174 | 235 | 0.84 (0.79–0.89) | 1,218 | 244 | 1.69 (1.60–1.79) | 1,204 | 241 | 3.79 (3.58–4.01) |
| All other | 69 | 14 | 0.02 (0.02–0.03) | 47 | 9 | 0.02 (0.02–0.03) | 41 | 8 | 0.02 (0.01–0.03) | 44 | 9 | 0.02 (0.02–0.03) | 59 | 12 | 0.04 (0.03–0.05) | 50 | 10 | 0.07 (0.05–0.09) | 37 | 7 | 0.12 (0.08–0.16) |
| TOTALb | 36,528 | 7,306 | 11.05 (10.94–11.17) | 39,580 | 7,916 | 19.57 (19.37–19.76) | 61,368 | 12,274 | 28.53 (28.30–28.75) | 87,595 | 17,519 | 42.27 (41.99–42.56) | 92,482 | 18,496 | 65.84 (65.41–66.27) | 60,781 | 12,156 | 84.76 (84.09–85.44) | 27,942 | 5,588 | 88.02 (86.99–89.06) |
| Malignant | 10,325 | 2,065 | 3.12 (3.06–3.18) | 8,896 | 1,779 | 4.39 (4.30–4.48) | 15,027 | 3,005 | 6.94 (6.83–7.05) | 25,684 | 5,137 | 12.38 (12.22–12.53) | 27,617 | 5,523 | 19.65 (19.42–19.89) | 17,291 | 3,458 | 24.14 (23.78–24.50) | 6,136 | 1,227 | 19.33 (18.85–19.82) |
| Non-Malignant | 26,203 | 5,241 | 7.94 (7.84–8.03) | 30,684 | 6,137 | 15.18 (15.01–15.35) | 46,341 | 9,268 | 21.59 (21.39–21.79) | 61,911 | 12,382 | 29.90 (29.66–30.14) | 64,865 | 12,973 | 46.18 (45.83–46.54) | 43,490 | 8,698 | 60.63 (60.06–61.20) | 21,806 | 4,361 | 68.69 (67.79–69.61) |
aRates are per 100,000 and age-adjusted to the 2000 US standard population.
bRefers to all brain tumors including histologies not presented in this table.
- Counts and rates are not presented when fewer than 16 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval; NOS, not otherwise specified.