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. Author manuscript; available in PMC: 2021 Oct 5.
Published in final edited form as: Curr Opin Genet Dev. 2021 Mar 21;68:64–70. doi: 10.1016/j.gde.2021.02.010

Figure 1.

Figure 1

Future research directions in understanding phenotypes and mechanisms of NRXN1 copy number variants.

Understanding how NRXN1 CNVs contribute to human disease will require coordinated efforts between iPSCs, where genetic interactions can be explored and high-throughput screens performed, and murine genetic models, where these mutations can be placed in neural circuit and behavioral contexts (Small animal imaging data modified from Canella et al., bioRxiv, 2020; doi: https://doi.org/10.1101/2020.08.05.237958).